Publication:
Pharmacokinetics of Doxycycline in Plasma and Milk after Intravenous and Intramuscular Administration in Dairy Goats

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dc.contributor.authorMartínez, José
dc.contributor.authorEscudero, Elisa
dc.contributor.authorBadillo, Elena
dc.contributor.authorYuste Pérez, María Teresa
dc.contributor.authorGalecio, Juan Sebastián
dc.contributor.authorMarin, Pedro
dc.contributor.departmentFarmacología
dc.date.accessioned2025-02-11T11:36:37Z
dc.date.available2025-02-11T11:36:37Z
dc.date.issued2024
dc.description© 2024 The authors This document is the published version of a published work that appeared in final form in Animals. . This document is made available under the CC-BY 4.0 license http://creativecommons.org/licenses/by/4.0 To access the final edited and published work see: https://doi.org/10.3390/ani14162416
dc.description.abstractDoxycycline is a second-generation tetracycline, marketed in different species for treating infections caused by susceptible bacteria. Little information is available on the pharmacokinetics of doxycycline in lactating goats. The objective of this study was to establish the disposition kinetics of doxycycline after parenteral administration (intravenous and intramuscular) in dairy goats and its elimination in milk. A cross-over model was designed (n = 6). Doxycycline was dosed at 5 mg/kg for intravenous administration and 20 mg/kg for extravascular administrations. Noncompartmental pharmacokinetic methods were used to calculate plasma concentration–time data. The Vz value suggests a moderate distribution of this antibiotic in goats, with a value of 0.85 L/kg. A low bioavailability (F = 45.60%) of doxycycline following an intramuscular injection was observed, with all animals exhibiting signs of lameness. Doxycycline rapidly crossed the blood–milk barrier, but exposure to the antimicrobial and the concentrations reached in milk were lower than those obtained in plasma. Although PK/PD ratios may be low with the pharmacokinetic data obtained with this formulation of doxycycline, at this dose and route of administration, doxycycline after IM administration could be useful for infections by moderate or highly susceptible bacteria in the mammary gland of goats. However, it may be necessary to test different doses of doxycycline or other routes of administration to achieve better surrogate markers and to establish repeated dosing regimens and clinical efficacy.es
dc.formatapplication/pdfes
dc.format.extent12es
dc.identifier.citationAnimals 2024, Vol. 14(16)
dc.identifier.doihttps://doi.org/10.3390/ani14162416
dc.identifier.urihttp://hdl.handle.net/10201/150252
dc.languageenges
dc.publisherMDPI
dc.relationSin financiación externa a la Universidades
dc.relation.publisherversionhttps://www.mdpi.com/2076-2615/14/16/2416
dc.rightsinfo:eu-repo/semantics/openAccesses
dc.rightsAttribution-NonCommercial-NoDerivatives 4.0 Internacional*
dc.rights.urihttp://creativecommons.org/licenses/by-nc-nd/4.0/*
dc.subjectBioavailabilityes
dc.subjectDairy goatses
dc.subjectDoxycyclinees
dc.subjectMilkes
dc.subjectPharmacokineticses
dc.titlePharmacokinetics of Doxycycline in Plasma and Milk after Intravenous and Intramuscular Administration in Dairy Goatses
dc.typeinfo:eu-repo/semantics/articlees
dspace.entity.typePublicationes
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