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Exploring the physicochemical and antimicrobial properties of gold-chitosan hybrid nanoparticles composed of varying chitosan amounts.

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dc.contributor.authorMohamady Hussein, Mohamed A.
dc.contributor.authorDíaz Baños, F. Guillermo
dc.contributor.authorGrinholc, Mariusz
dc.contributor.authorAbo Dena, Ahmed S.
dc.contributor.authorEl-Sherbiny, Ibrahim M.
dc.contributor.authorMegahed, Mosaad
dc.contributor.departmentQuímica Física
dc.date.accessioned2024-02-06T11:28:57Z
dc.date.available2024-02-06T11:28:57Z
dc.date.created2020
dc.date.issued2020
dc.description©<2020>. This manuscript version is made available under the CC-BY-NC-ND 4.0 license http://creativecommons.org/licenses/by-nc-nd/4.0/ This document is the, Accepted, version of a Published Work that appeared in final form in International Journal of Biological Macromolecules. To access the final edited and published work see: https://doi.org/10.1016/j.ijbiomac.2020.08.046
dc.description.abstractA green synthesis method for gold-chitosan hybrid nanoparticles (Au-CS hNPs) using different concentrations of CS as a capping/reducing agent is reported to investigate the effect of CS concentration on the physicochemical properties as well as the antimicrobial activity of the developed Au-CS hNPs. The as-synthesized Au-CS hNPs were characterized using visible spectrophotometry, FTIR, dynamic light scattering, DSC, XRD, SEM-EDX and TEM. The size of the formed hNPs ranges from 16.9 ± 3.9 nm (highest CS concentration) to 34.7 ± 7.6 nm (lowest CS concentration). It was noticed that increasing the amount of CS increases the ζ-potential from +25.1 to +53.1 mV and enhances the 6-months stability of the produced Au-CS hNPs. Furthermore, the obtained results indicated that the antimicrobial activity, in terms of MIC and CFU assays, is directly proportional to the amount of CS used in the preparation procedure. FTIR analysis revealed that the mechanism of formation of the Au-CS hNPs may involve complexation of CS with Au ions via its NH2 and OH groups followed by the chemical reduction of Au ions to metallic Au NPs. Eventually, higher amounts of CS are necessary for synthesizing highly stable Au-CS hNPs with small size, homogeneous shape and potent antibacterial/antifungal properties.es
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dc.format.extent20es
dc.identifier.doihttps://doi.org/10.1016/j.ijbiomac.2020.08.046
dc.identifier.eisbnInternational Journal of Biological Macromolecules vol. 162 (2020), Páginas: 1760-1769es
dc.identifier.issnPrint: 0141-8130
dc.identifier.urihttp://hdl.handle.net/10201/138734
dc.languageenges
dc.publisherElsevieres
dc.relationThe authors would like to thank the Islamic Development Bank (IDB), Jeddah, Saudi Arabia for funding this work through the IDB Merit Scholarship Program (Ref. 36/11207330, File No. 23/EGT/P34). This work has been partially supported by the European Commission (FEDER/ERDF), the Spanish MINECO (Ref. CTQ2017-87708-R) and the program of support to the research of the Seneca Foundation of Science and Technology of Murcia, Spain (Ref. 20977/PI/18).es
dc.relation.publisherversionhttps://www.sciencedirect.com/science/article/pii/S0141813020341337?via%3Dihub
dc.rightsinfo:eu-repo/semantics/openAccesses
dc.rightsAttribution-NonCommercial-NoDerivatives 4.0 Internacional*
dc.rights.urihttp://creativecommons.org/licenses/by-nc-nd/4.0/*
dc.subject.otherCDU::5 - Ciencias puras y naturaleses
dc.titleExploring the physicochemical and antimicrobial properties of gold-chitosan hybrid nanoparticles composed of varying chitosan amounts.es
dc.typeinfo:eu-repo/semantics/preprintes
dspace.entity.typePublicationes
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