Publication: Classification of routinelyprocessed anaplastic large cell tumours with a small panel of antibodies. An immunohistochemical study
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Date
1987
Authors
Henzen-Logmans, Sonja C. ; Mullink, Hendrik ; Vennegoor, Clauss ; Jo Hilgers, Jan Oort ; Meijer, Cris J.L.M.
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Publisher
Murcia : F. Hernández
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DOI
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info:eu-repo/semantics/article
Description
Abstract
A proportion of anaplastic large cell tumours
is difficult to classify on sections of routinely processed,
paraffin-embedded tissue. Differentiation into large cell
lymphoma, carcinoma, melanoma or sarcoma is important
in order to assess prognosis and proper treatment. Although
the use of immunohistochemistry has been reported in the
differentiation between some of these types of neoplasms,
no antibody panel, which can directly differentiate all of
them, has been described. In the present study we evaluated
the value of a panel of 5 antibodies for the classification
of 29 anaplastic large cell tumours, which could not be
classified by experienced pathologists using conventional
histological and histochemical techniques. The panel, which
can be used on routinely fixed paraffin-embedded tissue,
consisted of 5 different antibodies directed against keratin,
vimentin, the human milk-fat globule membrane antigen
MAM-6, a melanoma associated antigen and common
leucoyte antigen.
The use of this panel directly resulted in a definite
diagnosis in 95% of the cases and provided valuable
information for the diagnosis in the remaining cases. The
diagnosis was confirmed by additional marker studies and
electron microscopy. Moreover, clinical follow-up,
including treatment data, was in accordance with the
diagnosis based on the panel.
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