Publication:
Disposition kinetics and bioavailability of doxycycline after parenteral administrations in ewes

Simple item page
dc.contributor.authorMartínez, José
dc.contributor.authorEscudero Pastor, Elisa
dc.contributor.authorBadillo Puerta, Elena
dc.contributor.authorYuste Pérez, María Teresa
dc.contributor.authorGalecio Naranjo, Juan Sebastian
dc.contributor.authorMarín Carrillo, Pedro
dc.contributor.departmentFarmacología
dc.date.accessioned2025-01-28T11:49:35Z
dc.date.available2025-01-28T11:49:35Z
dc.date.issued2024-09-10
dc.description© 2024 The Authors. This manuscript version is made available under the CC-BY-NC-ND 4.0 license http://creativecommons.org/licenses/by-nc-nd/4.0/ This document is the Published Manuscript, version of a Published Work that appeared in final form in Research in Veterinary Science. To access the final edited and published work see https://doi.org/10.1016/j.rvsc.2024.105412
dc.description.abstractDoxycycline is a tetracycline, which have been marketed in different species for treating infections caused by susceptible bacteria. There is limited information on the disposition kinetics of this drug in ewes and this antimicrobial may be useful against several sheep pathogens that are common causes of morbidity and economic loss. Therefore, the aim of this work was to establish the pharmacokinetics of doxycycline after intravenous (IV) and extravascular (subcutaneous (SC) and intramuscular (IM)) administrations in this species. A cross-over model was designed (n = 6). Doxycycline was dosed at 5 mg/kg for IV administration and 20 mg/kg for extravascular administrations. Non-compartmental pharmacokinetic methods were used to calculate plasma concentration-time data. The value of apparent volume of distribution (Vz) suggests a moderate distribution of this antibiotic in sheep, with a value of 0.84 L/kg. The maximum concentrations achieved after extravascular administrations (Cmax) were similar, with no significant differences between the two routes of administration (IM and SC). However, doxycycline absorption was slower after SC administration than after IM administration, taking twice as long to reach maximum plasma concentration (tmax). Bioavailabilities after extravascular routes of administration were low and after IM administration doxycycline caused lameness in all animals. Therefore, the SC administration showed a better profile with respect to pharmacokinetic properties and safety. Future studies on the susceptibility of isolated sheep pathogens to doxycycline are needed to establish appropriate dosing regimens.
dc.formatapplication/pdfes
dc.format.extent6es
dc.identifier.citationResearch in Veterinary Science, 2024, Vol. 180 : 105412
dc.identifier.doihttps://doi.org/10.1016/j.rvsc.2024.105412
dc.identifier.issnPrint: 0034-5288
dc.identifier.issnElectronic: 1532-2661
dc.identifier.urihttp://hdl.handle.net/10201/149452
dc.languageenges
dc.publisherElsevier
dc.relationSin financiación externa a la Universidades
dc.relation.publisherversionhttps://www.sciencedirect.com/science/article/pii/S0034528824002790
dc.rightsinfo:eu-repo/semantics/openAccesses
dc.rightsAttribution-NonCommercial-NoDerivatives 4.0 Internacional*
dc.rights.urihttp://creativecommons.org/licenses/by-nc-nd/4.0/*
dc.subjectBioavailability
dc.subjectDoxycycline
dc.subjectPharmacokinetics
dc.subjectSheep
dc.subjectIntramuscular
dc.subjectSubcutaneous
dc.titleDisposition kinetics and bioavailability of doxycycline after parenteral administrations in eweses
dc.typeinfo:eu-repo/semantics/articlees
dspace.entity.typePublicationes
Files
Original bundle
Now showing 1 - 1 of 1
Thumbnail Image
Name:
Artículo publicado.pdf
Size:
1015.9 KB
Format:
Adobe Portable Document Format
Description:
Download
License bundle
Now showing 1 - 1 of 1
Thumbnail Image
Name:
license.txt
Size:
2.26 KB
Format:
Item-specific license agreed upon to submission
Description:
Download
Collections
Artículos