Publication: Brassica bioactives could ameliorate the chronic inflammatory condition of Endometriosis
Authors
García Ibánez, Paula ; Yepes Molina, Lucía ; Ruiz Alcaraz, Antonio José ; Martínez Esparza, M. ; Moreno, Diego A. ; Carvajal, Micaela ; García Peñarrubia, Pilar
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MDPI
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Description
© 2020 by the authors. This manuscript version is made available under the CC-BY 4.0 license http://creativecommons.org/licenses/by/4.0/
This document is the Published version of a Published Work that appeared in final form in International Journal of Molecular Sciences. To access the final edited and published work see https://doi.org/10.3390/ijms21249397
Abstract
Endometriosis is a chronic, inflammatory, hormone-dependent disease characterized
by histological lesions produced by the presence of endometrial tissue outside the uterine cavity.
Despite the fact that an estimated 176 million women are a ected worldwide by this gynecological
disorder, risk factors that cause endometriosis have not been properly defined and current treatments
are not e cient. Although the interaction between diet and human health has been the focus
of many studies, little information about the correlation of foods and their bioactive derivates
with endometriosis is available. In this framework, Brassica crops have emerged as potential
candidates for ameliorating the chronic inflammatory condition of endometriosis, due to their
abundant content of health-promoting compounds such as glucosinolates and their hydrolysis
products, isothiocyanates. Several inflammation-related signaling pathways have been included
among the known targets of isothiocyanates, but those involving aquaporin water channels have
an important role in endometriosis. Therefore, the aim of this review is to highlight the promising
e ects of the phytochemicals present in Brassica spp. as major candidates for inclusion in a dietary
approach aiming to improve the inflammatory condition of women a ected with endometriosis.
This review points out the potential roles of glucosinolates and isothiocyanates from Brassicas as
anti-inflammatory compounds, which might contribute to a reduction in endometriosis symptoms.
In view of these promising results, further investigation of the e ect of glucosinolates on chronic
inflammatory diseases, either as diet coadjuvants or as therapeutic molecules, should be performed.
In addition, we highlight the involvement of aquaporins in the maintenance of immune homeostasis.
In brief, glucosinolates and the modulation of cellular water by aquaporins could shed light on new
approaches to improve the quality of life for women with endometriosis.
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