Publication: Primary biliary cirrhosis PBC, antigen-presenting cells differ in their distribution in early and late stage PBC and involve the ductal...
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Date
1994
Authors
Rontogianni, D. ; Gerber, H. ; Zimmermann, Astrid
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Publisher
Murcia : F. Hernández
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DOI
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info:eu-repo/semantics/article
Description
Abstract
We have studied the distribution patterns of
antigen-presenting cells (APCs) in different stages of
primary biliary cirrhosis (PBC). 58% of cases with early
PBC (stages I and 11) exhibited dendritic APCs (S-loo+,
HLA-DR+, KiMlp+) in bile duct epithelia. In contrast,
APCs, were not detected in ductular proliferations
occurring in late PBC (stages I11 and IV), but occurred in
portal tracts and piecemeal necroses. There was a
correlation between the presence of APCs and HLA-DR
expression in bile ducts but, in contrast to former
studies. we noted a heterogeneous ductal HLA
expression. These observations support the hypothesis
that: 1) APC distribution in PBC may change as a
function of stage, involving hepatic parenchyma in late
PBC; 2) ductular epithelia may not represent a target for
immune attack, because APCs do not accumulate in
these structures; and 3) HLA expression in bile ducts
may be heterogeneous, suggesting one mechanism why
bile duct destruction in PBC does not take place in a
synchronous way.
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