Publication: Vasopressinergic neurons and the associated blood vessels in the rat anterior hypothalamus, an immunohistochemical study
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Date
1990
Authors
Ray, Prajnan K. ; Roy Choudhury, S.
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Publisher
Murcia : F. Hernández
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DOI
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info:eu-repo/semantics/article
Description
Abstract
The paraventricular (PVN) and supraoptic
(SON) nuclei of the hypothalamic neurosecretory system
have been extensively investigated by many workers.
The functional aspects of vasopressin secretion (elaborated
by the PVN and SON neurons) in relation to
the vasculature of the anterior hypothalamus are
also well documented. However, the available data
concerning vasopressin (VP) functions are largely based
on physiological studies. Corroborative morphological
correlation with regard to this has received little
attention. The present report elucidates the intricate
anatomical relationships between the VP-neurons and
the adjoining capillaries in the rat anterior hypothalamus.
A peroxidase-antiperoxidase (PAP) immunocytochemical
study, using a commercial VP antibody, was
carried out for this purpose. The observations are
interpreted from a functional standpoint.
VP-immunostained elements, i.e. the somata and the
processes (mainly dendrites), were localized (i) close to
the wall, (ii) on the endothelium, and (iii) occasionally, in
the lumen of the hypothalamic capillaries. The findings
provide immunocytochemical evidence that the vasopressinergic
elements are in direct relationship with the
hypothalamic vasculature. This raises some interesting
possibilities for the former to be involved in: (i) affecting
the permeability of the blood-brain barrier for transport
of various nutrient substances (important in aging and
Alzheimer's disease), (ii) inducing an alteration in the
water permeability of the brain vessels on which depends
the precise adjustment of brain water content and of
brain volume (fundamental to normal functioning of the
brain), and (iii) serving as osmoreceptors of the blood
flowing through the capillaries and thus providing a feedback
mechanism for VP modulation.
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