Publication: Lesions in lambs experimentally infected
Authors
Masot, A.J. ; Gázquez, A. ; Regodón, S. ; Franco, A. ; Redondo, E.
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Publisher
Murcia : F. Hernández
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DOI
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info:eu-repo/semantics/article
Description
Abstract
An experimental model was designed to
characterize lesions in the lung of lambs inoculated with
bovine respiratory syncytial virus (BRSV). 25 Merino
lambs of both sexes, with a live weight of 17+3 Kg,
received an intratracheal inoculation of 20 m1 saline
solution containing 1 . 2 6l~o 6 TCIDSOB RSV (strain
NMK-7) per ml. Lambs were laughtered 1, 3, 7, 11 and
15 postinoculation days (PID), and histopathological,
immunohistochemical and electron microscopic studies
were performed. Results reflected a series of lesions, the
most noteworthy of which were bronchiolitis obliterants
with destruction of the mucociliary apparatus, the
presence of syncytial cells in alveoli and a progressive
interstitial reaction. BRSV antigen was detected in lung
samples. These changes might be expected to decrease
the efficiency of respiratory tract defence mechanisms,
rendering the lung parenchyma susceptible to
opportunist bacteria1 infection.
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