Chitosan-nanoparticles effects on mucosal immunity: a systematic review

Collado-González,  Mar; Esteban Abad, María de los Ángeles

Publication:
Chitosan-nanoparticles effects on mucosal immunity: a systematic review

dc.contributor.author	Collado-González, Mar
dc.contributor.author	Esteban Abad, María de los Ángeles
dc.contributor.department	Biología Celular e Histología
dc.date.accessioned	2025-09-25T08:05:19Z
dc.date.available	2025-09-25T08:05:19Z
dc.date.copyright	© 2022, The Authors
dc.date.issued	2022-08-26
dc.description.abstract	Nanoparticles-based treatments is of utmost importance for aquaculture. In this scenario, chitosan-based nanoparticles have been proposed due to the properties of chitosan, which include mucoadhesiveness. Nevertheless, pivotal parameters of chitosan, such as degree of acetylation and molecular weight, are commonly underestimated in the available literature despite the influence they seem to have on the properties of chitosan-based nanoparticles. In this systematic review, the immunomodulator capacity of chitosan nanoparticles used as mucosal vaccines on teleost fish has been evaluated paying special attention to the chitosan properties. Four databases were used for literature search, yielding 486 documents, from which 14 meet the inclusion criteria. Only 21% of the available studies reported properly chitosan properties, which should be improved in future works to generate reproducible data as well as valuable information. To the best of our knowledge, this work objectively compares for the first time, by quantifying the mg of chitosan/g of fish applied in each study, the chitosan nanoparticle preparation and doses applied to fish, as well as the effects of the treatments applied on fish immune status.
dc.format	application/pdf
dc.format.extent	8
dc.identifier.citation	Fish and Shellfish Immunology 130 (2022) 1–8
dc.identifier.doi	https://doi.org/10.1016/j.fsi.2022.08.030
dc.identifier.issn	1050-4648
dc.identifier.uri	http://hdl.handle.net/10201/161589
dc.language	eng
dc.publisher	Elsevier
dc.relation	This project has received funding from the European Union’s Horizon 2020 Research and Innovation Programme under the Marie Sklodowska- Curie grant agreement No 101024387 and from the Proyecto PID2020- 113637RB-C21 de investigaci´on ﬁnanciado por MCIN/AEI/10.13039/ 501100011033
dc.relation.publisherversion	https://www.sciencedirect.com/science/article/pii/S1050464822005058?via%3Dihub
dc.rights	Attribution 4.0 International	*
dc.rights.accessRights	info:eu-repo/semantics/openAccess
dc.rights.uri	http://creativecommons.org/licenses/by/4.0/	*
dc.subject	Chitosan
dc.subject	Nanoparticles
dc.subject	Mucin
dc.subject	Mucus
dc.subject	Teleosts
dc.subject	Immunity
dc.subject.ods	No relacionado con ningún objetivo de desarrollo sostenible
dc.title	Chitosan-nanoparticles effects on mucosal immunity: a systematic review
dc.type	info:eu-repo/semantics/article
dspace.entity.type	Publication	es
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