Publication: Pituitary growth hormone secretory granules in streptozotocin-induced diabetic rats
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Date
1988
Authors
Masataka Shiino ; Toshiko Ishibashi
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Publisher
Murcia : F. Hernández
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DOI
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info:eu-repo/semantics/article
Description
Abstract
The ultrastructural features of growth
hormone (GH) secretory granules were observed by
immuno-gold procedure in the anterior pituitary glands
of streptozotocin (STZ) - induced diabetic rats. The
diabetic state of rats induced by one injection of STZ was
severely advanced at 10 months after the injection. The
cytoplasmic organella were revealed to be poorly
developed in GH-cells of the diabetic rats. The size of
immunoreactive GH-granules of 10-months-old diabetic
rats was smaller than that of sham-controls. The insulin
therapy in the diabetic rats resulted in a considerable
improvement in relation to the changes seen in the GHcells,
but the therapy did not return the profile of the
granule size distribution to that of the control group
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Citation
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