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The NLRP3 inflammasome is released as a particulate danger signal that amplifies the inflammatory response

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dc.contributor.authorBaroja-Mazo, Alberto
dc.contributor.authorGomez, Ana I.
dc.contributor.authorAmores-Iniesta, Joaquín
dc.contributor.authorCompan, Vincent
dc.contributor.authorBarberá-Cremades, María
dc.contributor.authorYagüe, Jordi
dc.contributor.authorRuiz-Ortiz, Estibaliz
dc.contributor.authorAntón, Jordi
dc.contributor.authorBuján, Segundo
dc.contributor.authorCouillin, Isabelle
dc.contributor.authorBrough, David
dc.contributor.authorArostegui, Juan I.
dc.contributor.authorMartínez Cáceres, Carlos Manuel
dc.contributor.authorMartín Sánchez, María Rosario Fátima
dc.contributor.authorPelegrín Vivancos, Pablo
dc.contributor.departmentBioquímica y Biología Molecular B e Inmunología
dc.date.accessioned2024-01-25T09:19:19Z
dc.date.available2024-01-25T09:19:19Z
dc.date.issued2014
dc.description©2014. This manuscript version is made available under the CC-BY-NC-ND 4.0 license http://creativecommons.org/licenses/by-nc-nd/4.0/ This document is the Accepte version of a Published Work that appeared in final form in Nature Immunology. To access the final edited and published work see https://doi.org/10.1038/ni.2919es
dc.description.abstractNLRP3 inflammasome assembly activates caspase-1 and mediates the processing and release of the leaderless cytokine IL-1β, and thereby plays a central role in the inflammatory response and in diverse human diseases. Here we report that upon caspase-1 activation oligomerized NLRP3-inflammasome particles are released from macrophages. Recombinant oligomeric protein particles composed of the adapter protein ASC or the cryopyrin-associated periodic syndromes (CAPS) mutant NLRP3 p.D303N, stimulate further caspase-1 activation extracellularly, and also intracellularly upon phagocytosis by surrounding macrophages. ASC oligomeric particles were found in the serum of patients with active CAPS, but not in patients with other inherited autoinflammatory diseases. Our findings support a model whereby the NLRP3-inflammasome, acting as an extracellular oligomeric complex, amplifies the inflammatory response.es
dc.formatapplication/pdfes
dc.format.extent52es
dc.identifier.citationNature Immunology, volume 15, nº 8, año 2014, páginas 738-748.
dc.identifier.doi10.1038/ni.2919
dc.identifier.issn1529-2916
dc.identifier.issn1529-2908
dc.identifier.urihttp://hdl.handle.net/10201/137732
dc.languageenges
dc.publisherNaturees
dc.relationInstituto Salud Carlos III (CD12/00523 and CD13/00059), Instituto Salud Carlos III-FEDER (EMER07/049, PS09/00120, PS09/01182, PI13/00174), Fundación Séneca (11922/PI/09), Fundación Mutua Madrileña (ID98FMM013).es
dc.relation.publisherversionhttps://www.nature.com/articles/ni.2919es
dc.rightsinfo:eu-repo/semantics/openAccesses
dc.rightsAttribution-NonCommercial-NoDerivatives 4.0 Internacional*
dc.rights.urihttp://creativecommons.org/licenses/by-nc-nd/4.0/*
dc.subjectMacrófagoses
dc.subjectCitocinases
dc.subjectInflamaciónes
dc.subjectInflamasomaes
dc.subjectPiroptosises
dc.subject.otherCDU::6 - Ciencias aplicadases
dc.titleThe NLRP3 inflammasome is released as a particulate danger signal that amplifies the inflammatory responsees
dc.typeinfo:eu-repo/semantics/articlees
dspace.entity.typePublicationes
relation.isAuthorOfPublicationa11bfbe4-fe50-4173-a96d-aa785375a6be
relation.isAuthorOfPublicationeefc2e40-b110-47b5-a081-bcf37256af4c
relation.isAuthorOfPublication547c4c2c-d906-4e1d-ae9a-0cdb40eef6d1
relation.isAuthorOfPublication.latestForDiscoverya11bfbe4-fe50-4173-a96d-aa785375a6be
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