Publication: Effect of Estradiol and Progesterone on Metabolic Biomarkers in Healthy Bitches
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Date
2013
Authors
Carrillo Sánchez, J. D. ; Tvarijonaviciute, Asta ; Cerón Madrigal, José Joaquín
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Facultades de la UMU::Facultad de Veterinaria
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Publisher
Wiley
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DOI
https://doi.org/10.1111/rda.12120
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info:eu-repo/semantics/article
Description
Abstract
El objetivo de este estudio fue evaluar la posible asociación entre los cambios hormonales que ocurren durante el estro y los biomarcadores relacionados con el metabolismo de la glucosa (glucosa e insulina), el metabolismo lipídico (perfil lipídico y BChE) y las adipocinas (adiponectina y grelina) en perras sanas. Con este propósito, se midieron estos analitos en suero de perras en dos momentos: antes (T1) y después (T2) del pico de LH, establecidos según las concentraciones de progesterona. Se observaron niveles aumentados de colesterol total (p < 0,01), colesterol unido a lipoproteínas de alta densidad (HDL-C) (p < 0,01), colesterol unido a lipoproteínas de baja densidad (LDL-C) (p < 0,01), adiponectina (p < 0,01) y grelina (p < 0,05) en T2 en comparación con T1. No se observaron cambios estadísticamente significativos en la glucosa sérica, insulina, modelo de evaluación de la homeostasis para la sensibilidad a la insulina (HOMA), triglicéridos ni en la BChE. Cuando se analizaron conjuntamente los datos de T1 y T2, la adiponectina sérica mostró correlación positiva con la progesterona (r = 0,353; p = 0,022) y con HDL-C (r = 0,307; p = 0,048), y correlación negativa con la insulina (r = -0,429; p = 0,005), con HOMA (r = -0,446; p = 0,003) y con BChE (r = -0,522; p < 0,001). La grelina mostró correlación negativa con el estradiol (r = -0,701; p = 0,004). La BChE se correlacionó negativamente con el estradiol (r = -0,441; p = 0,018) y con la glucosa (r = -0,343; p = 0,028), y positivamente con la insulina (r = 0,460; p = 0,003) y con HOMA (r = 0,505; p < 0,001). En conclusión, tras el pico de LH se producen cambios en los biomarcadores metabólicos en perras, caracterizados por un aumento de los lípidos (colesterol total, colesterol HDL y colesterol LDL) sin cambios en la actividad de BChE, así como un incremento en las concentraciones de adiponectina y grelina, sin cambios significativos en la glucosa ni en la insulina.
The aim of this study was to evaluate the possible association between hormonal changes that occur during oestrus and biomarkers related with glucose metabolism (glucose and insulin), lipid metabolism (lipidic profile and BChE) and adipokines (adiponectin and ghrelin) in healthy bitches. For this purpose, we measured these analytes in serum of bitches, at two times: before (T1) and after (T2) the LH peak that were established according to progesterone concentrations. Increased levels of total cholesterol (p < 0.01), high density lipoprotein cholesterol (HDL-C) (p < 0.01), low density lipoprotein cholesterol (LDL-C) (p < 0.01), adiponectin (p < 0.01) and ghrelin (p < 0.05) were observed at T2 in comparison with T1. No statistically significant changes were observed in serum glucose, insulin, homoeostasis model assessment for insulin sensitivity (HOMA), triglycerides and BChE. When all data of T1 and T2 were pooled, serum adiponectin showed positive correlation with progesterone (r = 0.353; p = 0.022) and HDL-C (r = 0.307; p = 0.048), and negative with insulin (r = −0.429; p = 0.005), HOMA (r = −0.446; p = 0.003) and BChE (r = −0.522; p < 0.001). Ghrelin showed negative correlation with estradiol (r = −0.701; p = 0.004). BChE was negatively correlated with estradiol (r = −0.441; p = 0.018) and glucose (r = −0.343; p = 0.028), and positively with insulin (r = 0.460; p = 0.003) and HOMA (r = 0.505; p < 0.001). In conclusion, changes in metabolic biomarkers occur in bitches after LH peak, characterized by increased lipids (total cholesterol, HDL cholesterol and LDL cholesterol) without changes in BChE activity, and increased adiponectin and ghrelin concentrations, without significant changes in glucose and insulin.
The aim of this study was to evaluate the possible association between hormonal changes that occur during oestrus and biomarkers related with glucose metabolism (glucose and insulin), lipid metabolism (lipidic profile and BChE) and adipokines (adiponectin and ghrelin) in healthy bitches. For this purpose, we measured these analytes in serum of bitches, at two times: before (T1) and after (T2) the LH peak that were established according to progesterone concentrations. Increased levels of total cholesterol (p < 0.01), high density lipoprotein cholesterol (HDL-C) (p < 0.01), low density lipoprotein cholesterol (LDL-C) (p < 0.01), adiponectin (p < 0.01) and ghrelin (p < 0.05) were observed at T2 in comparison with T1. No statistically significant changes were observed in serum glucose, insulin, homoeostasis model assessment for insulin sensitivity (HOMA), triglycerides and BChE. When all data of T1 and T2 were pooled, serum adiponectin showed positive correlation with progesterone (r = 0.353; p = 0.022) and HDL-C (r = 0.307; p = 0.048), and negative with insulin (r = −0.429; p = 0.005), HOMA (r = −0.446; p = 0.003) and BChE (r = −0.522; p < 0.001). Ghrelin showed negative correlation with estradiol (r = −0.701; p = 0.004). BChE was negatively correlated with estradiol (r = −0.441; p = 0.018) and glucose (r = −0.343; p = 0.028), and positively with insulin (r = 0.460; p = 0.003) and HOMA (r = 0.505; p < 0.001). In conclusion, changes in metabolic biomarkers occur in bitches after LH peak, characterized by increased lipids (total cholesterol, HDL cholesterol and LDL cholesterol) without changes in BChE activity, and increased adiponectin and ghrelin concentrations, without significant changes in glucose and insulin.
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Citation
Reprod Dom Anim 48, 520–524 (2013)
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