Publication: Expression of smoothelin
and smooth muscle actin in the skin
Authors
Aneiros Fernández, José ; Husein-ElAhmed, Husein ; Arias-Santiago, Salvador ; Campos, Antonio ; Carriel, Víctor ; Sánchez-Montesinos, Indalecio ; Garcia del Moral, Raimundo ; Sánchez, Guillermo ; O’Valle, Francisco ; Aneiros, J.
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Publisher
Editores F. Hernandez y Juan F. Madrid. Murcia, Universidad de Murcia, Departamento de Biologia Celular e Histologia
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DOI
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info:eu-repo/semantics/article
Description
Abstract
Introduction: Smoothelin is a cytoskeletal
protein of differentiated smooth muscle cells with
contractile capacity, distinguishing it from other smooth
muscle proteins, such as smooth muscle actin (SMA).
Objective: To evaluate the expression of smoothelin
and SMA in the skin in order to establish specific
localizations of smoothelin in smooth muscle cells with
high contractile capacity and in the epithelial component
of cutaneous adnexal structures. Methods:
Immunohistochemical analysis (smoothelin and SMA)
was performed in 18 patients with normal skin.
Results: SMA was expressed by the vascular
structures of superficial, deep, intermediate and
adventitial plexuses, whereas smoothelin was
specifically expressed in the cytoplasm of smooth
muscle cells of the deepest vascular plexus and in no
other plexus of the dermis. The hair erector muscle
showed intense expression of smoothelin and SMA.
Cells with nuclear expression of smoothelin and
cytoplasmic expression of SMA were observed in the
outer root sheath of the inferior portion of the hair
follicles and intense cytoplasmic expression in cells of
the dermal sheath to SMA.
Conclusions: We report the first study of smoothelin
expression in normal skin, which differentiates the
superficial vascular plexus from the deep. The deep
plexus comprises vessels with high contractile capacity,
which is important for understanding dermal
hemodynamics in normal skin and pathological
processes. We suggest that the function of smoothelin in
the outer root sheath may be to enhance the function of
SMA, which has been related to mechanical stress.
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