Publication: Ultrastructural evidence of the evolutional process in malakoplakia
Authors
Jung, Yeon Seung ; Chung, Dong Yong ; Kim, Eun Jin ; Cho, Nam Hoon
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Publisher
Universidad de Murcia, Departamento de Biologia Celular e Histiologia
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DOI
https://doi.org/10.14670/HH-18-150
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info:eu-repo/semantics/article
Description
Abstract
Context. Malakoplakia can be caused by
incomplete digestion of Escherichia coli by lysosomes,
leading to recurrent urinary tract infections and
consequential mass-forming events that mimic tumors.
Objectives. By using ultrastructural findings, we
aimed to specify the process of phagolysosome to evoke
malakoplakia. Design. We observed a series of processes
to form a peculiar Michaelis-Gutmann (MG) body in
three patients with malakoplakia and compared with
xanthogranulomatous pyelonephritis.
Results. The ultrastructural findings were realigned
according to the sequence of events as pre-phagosomal,
phagosomal, and post-phagosomal stages. For the
mature MG body, numerous lysosomal aggregates
targeting pathogens and subsequent incomplete digestion
are prerequisite factors for the pre-phagosomal stage.
Scattered lamellated residue is late evidence of the pre-
phagosomal stage. Phagosomes can be formed by the
fusion of multiple pathogens and multiple lysosomes.
We utilized transmission and scanning electron
microscopy to speculate on the process of
phagolysosomal formation.
Conclusion. The recognition of E. coli captured by
phagosomes or partially damaged by lysosomal attack
within the cell was recorded for the first time.
Furthermore, SEM observation was performed on
human tissue
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Citation
Histology and Histopathology Vol. 35, nĀŗ 2 (2020)
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Este Ćtem estĆ” sujeto a una licencia Creative Commons. http://creativecommons.org/licenses/by-nc-nd/4.0/