Pathogenic role of TGF-ß in the
progression of podocyte diseases

Lee, Hyun Soon

Publication:
Pathogenic role of TGF-ß in the progression of podocyte diseases

dc.contributor.author	Lee, Hyun Soon
dc.date.accessioned	2015-11-30T18:52:55Z
dc.date.available	2015-11-30T18:52:55Z
dc.date.issued	2011
dc.description.abstract	In patients with progressive podocyte diseases, such as focal segmental glomerulosclerosis and membranous nephropathy, there is enhanced expression of transforming growth factor (TGF-ß) in podocytes. Biomechanical strain in these diseases may cause overexpression of TGF-ß and angiotensin II (Ang II) by podocytes. Oxidative stress induced by Ang II may activate the latent TGF-ß. Increased TGF-ß activity by podocytes may induce not only the thickening of the glomerular basement membrane (GBM), but also podocyte apoptosis and/or detachment from the GBM, initiating the development of glomerulosclerosis. Furthermore, mesangial matrix expansion frequently occurs in podocyte diseases in association with the development of glomerulosclerosis. This review examines open questions on the pathogenic role of TGF- ß that links podocyte injury to GBM thickening, podocyte loss, mesangial matrix expansion and glomerulosclerosis in podocyte diseases. It also describes paracrine regulatory mechanisms of podocyte TGF-ß on mesangial cells leading to increased matrix synthesis.	es
dc.format	application/pdf	es
dc.format.extent	10	es
dc.identifier.issn	0213-3911
dc.identifier.uri	http://hdl.handle.net/10201/46925
dc.language	eng	es
dc.publisher	Murcia: F. Hernández	es
dc.relation.ispartof	Histology and histopathology, Vol. 26, nº 1 (2011)	es
dc.rights	info:eu-repo/semantics/openAccess	es
dc.subject	Oxidative stress	es
dc.subject	Podocyte apoptosis	es
dc.subject.other	616 - Patología. Medicina clínica. Oncología	es
dc.title	Pathogenic role of TGF-ß in the progression of podocyte diseases	es
dc.type	info:eu-repo/semantics/article	es
dspace.entity.type	Publication	es