Publication: Pathogenic role of TGF-ß in the
progression of podocyte diseases
Authors
Lee, Hyun Soon
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Publisher
Murcia: F. Hernández
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DOI
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info:eu-repo/semantics/article
Description
Abstract
In patients with progressive podocyte
diseases, such as focal segmental glomerulosclerosis and
membranous nephropathy, there is enhanced expression
of transforming growth factor (TGF-ß) in podocytes.
Biomechanical strain in these diseases may cause
overexpression of TGF-ß and angiotensin II (Ang II) by
podocytes. Oxidative stress induced by Ang II may
activate the latent TGF-ß. Increased TGF-ß activity by
podocytes may induce not only the thickening of the
glomerular basement membrane (GBM), but also
podocyte apoptosis and/or detachment from the GBM,
initiating the development of glomerulosclerosis.
Furthermore, mesangial matrix expansion frequently
occurs in podocyte diseases in association with the
development of glomerulosclerosis. This review
examines open questions on the pathogenic role of TGF-
ß that links podocyte injury to GBM thickening,
podocyte loss, mesangial matrix expansion and
glomerulosclerosis in podocyte diseases. It also
describes paracrine regulatory mechanisms of podocyte
TGF-ß on mesangial cells leading to increased matrix
synthesis.
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