Publication: Measurement of Trace Elements (Zinc, Copper, Magnesium, and Iron) in the Saliva of Horses: Validation Data and Changes in Equine Gastric Ulcer Syndrome (EGUS)
Authors
Muñoz-Prieto, Alberto ; Cerón, José Joaquín ; Tecles, Fernando ; Cuervo, María Martín ; Contreras-Aguilar, Maria Dolores ; Ayala de la Peña, Ignacio ; Oudada-Guillén, Adrián ; Pardo-Marín, Luis ; Hansen, Sanni
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Publisher
MDPI
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DOI
https://doi.org/10.3390/ani14121724
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info:eu-repo/semantics/article
Description
© 2024. The authors. Once the embargo has passed, this document will be available under the CC-BY 4.0 license http://creativecommons.org/licenses/by /4.0/
This document is the published version of a published work that appeared in final form in Animals
To access the final work, see DOI: https://doi.org/10.3390/ani14121724
Abstract
The objective of this study was to evaluate the possible use of spectrophotometric assays
for the measurement of trace elements, including Zinc (Zn), Copper (Cu), Magnesium (Mg), and iron
(Fe) in the saliva of horses and study their possible changes in equine gastric ulcer syndrome (EGUS).
EGUS is a highly prevalent disease, with a current high incidence due to the increase in intensive
management conditions. There are two EGUS diseases: equine squamous gastric disease (ESGD)
and equine glandular gastric disease (EGGD), which can appear individually or together. For this
purpose, automated spectrophotometric assays for measuring these analytes in horse saliva were
analytically validated. Then, these analytes were measured in the saliva of horses with only ESGD,
only EGGD, both ESGD and EGGD and a group of healthy horses. The methods used to measure
the analytes were precise and accurate. Horses diagnosed with EGGD presented significantly lower
levels of Zn and Mg. Fe concentrations were significantly lower in the saliva of horses with ESGD and
EGGD. Overall, these results indicate that there are changes in trace elements in saliva in EGUS that
could reflect the physiopathological mechanisms involved in this process and open the possibility of
using trace elements as biomarkers of this syndrome.
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Citation
Animals 2024, 14, 1724
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