Publication: In favour of an oncofoetal concept of bronchogenic carcinoma development
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Date
1994
Authors
Ten Have-pbroek, A.A.W. ; Benfield, J.R. ; Hammond, W.G. ; Teplitz, R.L. ; Dijkman, J.H.
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Publisher
Murcia : F. Hernández
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DOI
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info:eu-repo/semantics/article
Description
Abstract
Our recent studies in a heterotopic
model of non-small cell lung cancer in dogs (subcutaneous
bronchial autografts treated with 3-
~i iethylchola~i threnhea) ve provided evidence that
alveolar type I1 cells may newly arise during initial
phases of bronchial carcino-genesis. In the light of
these novel findings, which are in agreement with
our observations in human non-small cell lung cancer,
and in \~iew of present insighrs into embryonic
lung differentiation, we discuss evidence that favours
a new1. oncofoetal concept of bronchogenic carcinoma
development. According to this concept, the primary
cells of origin for these tilmors are undifferentiated
primordial-like cells that derive from bronchial
epithelial cells present in major bronchi or their
divisions by retrodifferentiation. Such primordiallike
cells of origin ~~nde rgnoo vel differentiation into
the potential (alveolar, bronchial or primordial)
tumor stem cells, which occupy the dividing cellular
layers of the (pre)neoplastic lesions and constitute
the actively dividing and invading part of the neoplasn~.
Examples of tumors that may originate from alveolar
tunlor stem cells are carcinon~aso f the bronchioloalveolar,
papillary, acinar, and adenoid-cystic types.
Squamous cell carcinon~asc ould possibly belong
to this group as well, but much more evidence is
required to reach conclusions regarding this type of
cancer.
We suggest that epithelial retrodifferentiation
followed by novel differentiation (oncofoetal
mechanism) is fundamental in bronchial carcinogenesis.
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