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In situ detection of APRIL-rich niches for plasma-cell survival and their contribution to B-cell lymphoma development

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dc.contributor.authorBurjanadze, M.es
dc.contributor.authorMatthes, T.es
dc.date.accessioned2013-09-24T11:40:15Z
dc.date.available2013-09-24T11:40:15Z
dc.date.issued2009
dc.description.abstractA proliferation inducing ligand (APRIL) is one of the most recently cloned members of the tumor necrosis factor (TNF) family. Early experiments implicated a pathophysiological role for APRIL in the promotion of solid tumors. Later, identification of APRIL receptors on B lymphocytes indicated a physiological role for APRIL in humoral responses. We have been able to generate antibodies that detect APRIL protein in human tissues. The study of in situ APRIL expression showed that APRIL mainly regulates late stages of B-cell humoral responses. It also provided evidence that APRIL may modulate tumor development in patients, but only for specific B-cell malignancies. Here, we will review to what extent fine characterization of in situ expression adds valuable information on APRIL (patho) physiological functions.es
dc.formatapplication/pdfes
dc.format.extent6es
dc.identifier.issn0213-3911es
dc.identifier.urihttp://hdl.handle.net/10201/36063
dc.languageenges
dc.publisherMurcia : F. Hernándezes
dc.relation.ispartofHistology and histopathologyes
dc.rightsinfo:eu-repo/semantics/openAccesses
dc.subjectInflammationes
dc.subjectHumoral immunityes
dc.subject.other57 - Biologíaes
dc.titleIn situ detection of APRIL-rich niches for plasma-cell survival and their contribution to B-cell lymphoma developmentes
dc.typeinfo:eu-repo/semantics/articlees
dspace.entity.typePublicationes
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Histology and histopathology Vol.24, nº8 (2009)