Publication: In situ detection of APRIL-rich niches for plasma-cell survival and their contribution to B-cell lymphoma development
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Date
2009
Authors
Burjanadze, M. ; Matthes, T.
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Publisher
Murcia : F. Hernández
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DOI
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info:eu-repo/semantics/article
Description
Abstract
A proliferation inducing ligand (APRIL) is
one of the most recently cloned members of the tumor
necrosis factor (TNF) family. Early experiments
implicated a pathophysiological role for APRIL in the
promotion of solid tumors. Later, identification of
APRIL receptors on B lymphocytes indicated a
physiological role for APRIL in humoral responses. We
have been able to generate antibodies that detect APRIL
protein in human tissues. The study of in situ APRIL
expression showed that APRIL mainly regulates late
stages of B-cell humoral responses. It also provided
evidence that APRIL may modulate tumor development
in patients, but only for specific B-cell malignancies.
Here, we will review to what extent fine characterization
of in situ expression adds valuable information on
APRIL (patho) physiological functions.
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Citation
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