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Changes in saliva proteins in two conditions of compromised welfare in pigs: T an experimental induced stress by nose snaring and lameness

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dc.contributor.authorEscribano Tortosa, Damián
dc.contributor.authorHorvatić, Anita,
dc.contributor.authorContreras Aguilar, María Dolores
dc.contributor.authorGuillemin, Nicolas,
dc.contributor.authorCerón Madrigal, José Joaquín
dc.contributor.authorTecles Vicente, Fernando
dc.contributor.authorMartínez Miró, Silvia
dc.contributor.authorEckersall, Peter David
dc.contributor.authorManteca, Xavier
dc.contributor.authorMrljak, Vladimir
dc.contributor.departmentProducción Animal
dc.date.accessioned2025-01-17T08:50:37Z
dc.date.available2025-01-17T08:50:37Z
dc.date.issued2019-06-19
dc.description© 2019 Elsevier Ltd. al right reserved. This document is the Published version of a Published Work that appeared in final form in Research in Veterinary Science. To access the final edited and published work see https://doi.org/10.1016/j.rvsc.2019.06.008es
dc.description.abstractThe aim of this study was to identify biological pathways and proteins differentially expressed in saliva of pigs in two conditions of compromised welfare: an acute stress consisting of restraint with a nose snare and in pigs with lameness which is a highly frequent problem in the swine industry. For this purpose, high-resolution quantitative proteomics based on Tandem Mass Tags labelling was used. Four proteins showed significant differences in the conditions of compromised welfare, namely cornulin, the heat shock protein 27 and lactate dehydrogenase (LDH), that showed significant increases, whereas immunoglobulin J chain showed a significant decrease. LDH, which was the protein that showed the highest differences, was selected for validation and clinical evaluation as a diagnostic biomarker. Significant changes in this protein were observed between pigs restrained with a nose snare and pigs with lameness compared with healthy pigs when measured with available commercial assays in a larger population of pigs. In conclusion, this study reports that in situations of compromised welfare on farm, such as acute stress and lameness in pigs, there are changes in proteins and metabolic pathways in saliva, and describes a series of proteins that could potentially be used as biomarkers for both short term acute stress and longer term chronic stress of lameness. These biomarkers would have the advantage of being measured in saliva by a noninvasive and not stressful collection sampling procedure.es
dc.embargo.termsSi
dc.formatapplication/pdfes
dc.format.extent8es
dc.identifier.doihttps://doi.org/10.1016/j.rvsc.2019.06.008
dc.identifier.eisbnResearch in Veterinary Science 125 (2019) 227–234es
dc.identifier.issnPrint: 0034-5288
dc.identifier.issnElectronic: 1532-2661
dc.identifier.urihttp://hdl.handle.net/10201/148645
dc.languageenges
dc.publisherElsevieres
dc.relationThis work was supported by a help of mobility “Jose Castillejo” of the “Ministerio de Educación, Cultura y Deporte” within the framework of the State Program for the Promotion of Talent and its Employability in I+D+i, the State Subprogram of Mobility, of the State Plan (Spain). DE has a post-doctoral fellowshisp “Juan de la Cierva Formación” supported by the “Ministerio de Economía y Competitividad”, Spain. M.D.C.-A. was granted by the predoctoral contract ‘FPU’ of University of Murcia (R-605/2016), Spain. AH, NG, PDE and VM were supported by the European Commission FP7 ERA Chair “VetMedZg” Project (grant number 621394).es
dc.relation.publisherversionhttps://www.sciencedirect.com/science/article/pii/S0034528819304564?via%3Dihub
dc.rightsinfo:eu-repo/semantics/embargoedAccesses
dc.subjectLameness
dc.subjectPigs
dc.subjectSaliva
dc.subjectStress
dc.subjectTMT analysis
dc.subjectWelfare
dc.subject.otherCDU::6 - Ciencias aplicadas::63 - Agricultura. Silvicultura. Zootecnia. Caza. Pesca::636 - Veterinaria. Explotación y cría de animales. Cría del ganado y de animales domésticoses
dc.titleChanges in saliva proteins in two conditions of compromised welfare in pigs: T an experimental induced stress by nose snaring and lamenesses
dc.typeinfo:eu-repo/semantics/articlees
dspace.entity.typePublicationes
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