Publication:
Abnormal distribution of CD45 isoforms expressed by CD4+ and CD8+ T cells in rheumatoid arthritis

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Abnormal distribution of CD45 isoforms expressed by CD4....pdf(2.69 MB)
Date
2000
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Authors
Mamoune, A. ; Durand, V. ; Le Goff, P. ; Pennec, Y.L. ; Youinou, P. ; Le Corre, R.
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Publisher
Murcia : F. Hernández
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Description
Abstract
CD45RO+ T cells are referred to as memory or helper-inducer while CD45RA+ T cells are regarded as naive or suppressor-inducer T cells. The former population predominates in the peripheral blood and even more in the synovial fluid of patients with rheumatoid arthritis, to the expense of the latter population. Within the CD45RB+ compartment, there appears to be more of the fully-differentiated than of the early-differentiated CD4+ T cells. In spite of the fact that these lymphocytes are close to undergoing apoptosis, this programmed cell death is inhibited in the rheumatoid synovium.
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Rheumatoid arthritis , Apoptosis
Citation
URI
http://hdl.handle.net/10201/19311
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Histology and histopathology Vol.15, nº 2 (2000)
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