Publication: Association of sinus histiocytosis with massive lymphadenopathy and idiopathic hypereosinophilic syndrome
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Date
1987
Authors
Hernández, Dimas ; Gutierrez, Luis ; Duque, Herminia ; Olavarria, Renato ; Muci, Rafael ; Wunaii, Herman
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Publisher
Murcia : F. Hernández
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DOI
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info:eu-repo/semantics/article
Description
Abstract
A patient was evaluated because of edema,
pruritus and generalized painless lymphadenopathy.
Laboratory tests showed marked eosinophilia without
known etiology. CT scan of abdomen revealed multiple
lymph nodes in retroperitoneal area. Lymph node biopsy
was reported as sinus histiocytosis, bone marrow biopsy
showed hipercellularity with marked infiltration of
normal eosinophils. During his admission he developed
Coombs positive hemolytic anaemia. Once he was stable,
a laparotomy was performed and the patient died two
days later because of septic shock. Autopsy revealed
sinus histiocytosis with massive lymphadenopathy
(SHML) with extranodal involvement of duodenum,
spleen and prostate; septic liver and spleen, pyelonephritis,
marked infiltration of eosinophilis in lymph nodes,
spleen, liver duodenum and lungs. To the best of our
knowledge, this is the first case report of the association
of SHML and Idiopathic Hypereosinophilic Sundrome
(HES) .
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