Publication: E-cadherin, β-catenin, and α2β1 and α3β1 integrin expression in primary oral squamous cell carcinoma and its regional metastasi
Authors
Quirino Silveira Soares, Mariana ; Andrade Mendonça, Juliana ; Oliveira Morais, Marília ; Rodrigues Leles, Claudio ; Carvalho Batista, Aline ; Mendonça, Elismauro Francisco
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Publisher
F. Hernández y Juan F. Madrid. Universidad de Murcia: Departamento de Biología Celular e Histología
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DOI
10.14670/HH-11-616
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info:eu-repo/semantics/article
Description
Abstract
. To investigate E-cadherin, β-catenin, and
α2β1 and α3β1 integrins in 40 samples of nonmetastatic and metastatic oral squamous cell carcinoma
(OSCC) with positive cervical lymph nodes (LN).
Immunohistochemistry was used to evaluate expression
in the lesion center (LC) and invasive tumor front (ITF)
of non-metastatic (n=18) and metastatic (n=22) OSCC
and in the LN on the metastatic neoplastic cells (MNC;
n=22). In metastatic OSCC, E-cadherin and β-catenin
presented significantly lower cytoplasmic membrane
expression in the ITF and MNC when compared to the
LC and lower cytoplasmic expression in MNC when
compared to the LC and ITF (p<0.05). Integrins α2β1
and α3β1 showed high cytoplasmic expression in the
LC, ITF and MNC (p>0.05). A positive correlation was
observed between E-cadherin cytoplasmic expression
and α2β1 (ρ=0.860) and α3β1 (ρ=0.975) expression.
When comparing the primary sites of metastatic and
non-metastatic disease, β-catenin presented lower
cytoplasmic membrane (p=0.013) expression in
metastatic OSCC. E-cadherin presented low expression
and the integrins high expression in both groups.
Abnormal expression of β-catenin and E-cadherin
associated with high expression of α2β1 and α3β1
integrins contribute to LN metastasis in OSCC.
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