Publication: Compensatory adrenal growth in aldosterone-treated male and female hamsters
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Date
1989
Authors
Kasprzak, A. ; Malendowicz, L.K.
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Publisher
Murcia : F. Hernández
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DOI
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info:eu-repo/semantics/article
Description
Abstract
The aim of the study was to investigate the
compensatory adrenal growth in aldosterone-treated
male and female hamsters. Hemiadrenalectomised and
sham-operated animals were treated for 5 days with a
daily d-aldosterone dose of 25 pglanimal.
In both male and female aldosterone-treated hamsters
monoadrenalectomy did not change the relative
adrenal weight if compared with sham-operated groups.
The fasciculata zonae of monoadrenalectomised aldosterone-
treated males was larger and contained more
parenchyma1 cells than in appropriate control group.
There was no difference in the volume of adrenocortical
zones, average cell volume and in cell number between
sham-operated and unilaterally adrenalectomised females.
In vitro 3H-thymidine incorporation per adrenal was
markedly higher in monoadrenalectomised than in
sham-operated aldosterone-treated males while the
opposite was true for female hamsters.
Thus, the action of aldosterone on CAG in the
hamster seems to depend on sex, with no effect in males
and inhibitory action in females.
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