Publication: The origin and differentiation of adrenocortical cells in rats with portacaval shunt. A structural and ultrastructural study
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Date
1988
Authors
Domenici Lombardo, L. ; Cortesini, C.
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Publisher
Murcia : F. Hernández
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DOI
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info:eu-repo/semantics/article
Description
Abstract
Tlie foi-mation of adreiiocortical cells in thc
rat was st~idicd by light and elcctron inicroscopy in an
csperinicntal modcl. namcly portacuval shunt (P.C.S.).
in v.liicli .;trong hypcrpl~isia of the cells oí' the c¿ipsulairrgion
occurs. The results of this study indicate that in
physiological cunditions at the lcvel of thc adrenal glnnd
cnpsulc sonic epithclial cells, morphologically
distinguisliable as dark and clcnr cells, are found which
can he interprctcd as precursors of adrenocortical cells.
Fi-orn observations of intermediate forrns betwccn
cupsular precursors arid mature adrcnocortical cells.
wliich are found in high numbers following P.C.S.. it
seellis that tlie dark prccursors give rise to cclls of thc
zoiia glonicriilosa and the clcar precursors e\-olve into
cclls of tlie zona intermedia, which are to he considercd
as thc starting point for the formiition of cells «f thc zona
fnsciculata.
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