Histology and histopathology Vol. 3, nº 2 (1988)

Ir a Estadísticas

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http://hdl.handle.net/10201/177338

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Pulmonary changes in rats following administration of 3-methylindole in cremophore EL
(Murcia : F. Hernández, 1988) Kiorpes, Anthony L.; Keith, lngegerd
3-methylindole (3-MI) dissolvcd in the lipopliilic carrier Crcmophorc EL was administered intraperitoneally to male, twelve-week-old Sprague- Dawley rats. Gross and histopathologic changes in the lurigs were studied using light microscopy rit thrcc timepcriods fc>llowing administration: 16, 24. and 46 hours. Both 3-MI1 and Cremophore caused changes in bronchiolar epithelium at 16 hours. By 46 hours, Cremophore-injected rats showed no effects of the carrier; whercas, 3-MI rats showed severe lung changes characterizcd by aii-way epithelial and pulmonary vascular endothelial nccrosis and slougliing, cellular infiltration by lyniphocytes and macrophages. perivascular edema, alveolar edema, and lymph stasis. Grossly, the controls showed no effect of the carrier and nonc died during the st~idiesI. n contrast, 3-MI injected rats quickly became lethargic and displayed tachypiiea. anorexia, and progressivc respiratory distress. Two of five 3-M1 rats in the final group died just prior to 46 hours. Al1 of this group had grossly congested lungs and ninrked pleural effusion. The lesions and timc course showed similarities to those observed in ruminants and mice. We conclude thnt 3-M1 in Cremophore causes an acute 1"-ogressive pneumonitis in rats and suggest that the rats niay be a suitable model for 3-MI-induced and similar tosic lung diseases in domestic animals and people
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Ultrastructural changes of the renal cortex after septic shock in rats
(Murcia : F. Hernández, 1988) Achparaki, A.; Kotzampassi, K.; Eleftheriadis, E.; Foroglou, Ch.
Open Access
The origin and differentiation of adrenocortical cells in rats with portacaval shunt. A structural and ultrastructural study
(Murcia : F. Hernández, 1988) Domenici Lombardo, L.; Cortesini, C.
Tlie foi-mation of adreiiocortical cells in thc rat was st~idicd by light and elcctron inicroscopy in an csperinicntal modcl. namcly portacuval shunt (P.C.S.). in v.liicli .;trong hypcrpl~isia of the cells oí' the c¿ipsulairrgion occurs. The results of this study indicate that in physiological cunditions at the lcvel of thc adrenal glnnd cnpsulc sonic epithclial cells, morphologically distinguisliable as dark and clcnr cells, are found which can he interprctcd as precursors of adrenocortical cells. Fi-orn observations of intermediate forrns betwccn cupsular precursors arid mature adrcnocortical cells. wliich are found in high numbers following P.C.S.. it seellis that tlie dark prccursors give rise to cclls of thc zoiia glonicriilosa and the clcar precursors e\-olve into cclls of tlie zona intermedia, which are to he considercd as thc starting point for the formiition of cells «f thc zona fnsciculata.
Open Access
Alkaline phosphatase activity of the IVth ventricular choroidal epithelium of rats during embryonic and neonatal development
(Murcia : F. Hernández, 1988) Takafumi Yoshioka; Osamu Tanaka; Hiroki Otani; Haruo Shinohara; Kenichirou Inomata
Open Access
Morphological study of the rat pituitary follicle stimulating hormone cells after alternate day treatment with luteinizing hormone-releasing hormone (LHRH)
(Murcia : F. Hernández, 1988) Carbajo-Pérez, E.; Rubio, M.; Carbajo, S.; Sánchez, F.; Vázquez, R.

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