Publication: The cytoskeleton in skeletal, cardiac and smooth muscle cells
Authors
Stromer, M. H.
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Publisher
F. Hernández y Juan F. Madrid. Universidad de Murcia. Departamento de Biología Celular e Histología
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DOI
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info:eu-repo/semantics/article
Description
Abstract
The muscle cell cytoskeleton consists of
proteins or structures whose primary function is to link,
anchor or tether structural components inside the cell.
Two important attributes of the cytoskeleton are strength
of the various attachments and flexibility to accommodate the changes in cell geometry that occur during
contraction. In striated muscle cells, extramyofibrillar
and intramyofibrillar domains of the cytoskeleton have
been identifi ed , Evidence of the extramyofibrillar
cytoskeleton is seen at the cytoplasmic face of the
sa rcolemma in striated muscle where vinculin- and
dystrophin-rich costameres adjacent to sarcomeric Z
lines anchor intermedi a te filaments that span from
peripheral myofibrils to the sarcolemma. Intermediate
filaments also link Z lines of adjacent myofibrils and
may, in some muscles, link successive Z lines within a
myofibril at the surface of the myofibril. The intramyofibrillar cytoskeletal domain includes elastic titin
filaments from adjacent sarcomeres that are anchored in
the Z line and continue through the M line at the center
of the sa rcomere; inelastic nebulin filaments also
anchored in the Z line and co-extensible with thin
filaments; the Z line, which also anchors thin filaments
from adjacent sarcomeres; and the M line, which forms
bridges between the centers of adjacent thick filaments,
In smooth muscle, the cytoskeleton includes adherens
junctions at the cytoplasmic face of the sarcolemma,
which a nchor B-actin filaments and intermediate
filaments of the cytoskeleton, and dense bodies in the
cytoplasm, which also anchor actin filaments and
intermediate filaments and which may be the interface
between cytoskeletal and contractile elements.
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