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A useful immunohistochemical approach to evaluate intraductal proliferative lesions of the breast and to predict their prognosis

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dc.contributor.authorOmi, Yoko
dc.contributor.authorYamamoto, Tomoko
dc.contributor.authorOkamoto, Takahiro
dc.contributor.authorObara, Takao
dc.contributor.authorKobayashi, Makio
dc.date.accessioned2015-11-30T18:31:49Z
dc.date.available2015-11-30T18:31:49Z
dc.date.issued2011
dc.description.abstractAn examination was performed on 16 intraductal proliferative breast lesions diagnosed as intraductal papillomas (IP) or usual ductal hyperplasia (UDH), which were followed up for more than 3 years. An immunohistochemical marker panel combining myoepithelial markers, high-molecular-weight keratin (HMWK) and neuroendocrine markers was used. Two of 11 IP cases were re-evaluated as atypical ductal hyperplasia (ADH) and ductal carcinoma in situ (DCIS). These cases developed breast cancer after the first operation. One IP case showed repeated recurrences. None of the other IP and UDH cases had breast cancer or recurrence. The ADH, DCIS and the recurrent IP showing a solid growth lacked myoepithelia, but the recurrent IP expressed HMWK, immunohistochemically. Interestingly, these three lesions were weakly positive for neuroendocrine markers. All other IPs and UDHs, including lesions having solid components, were negative for neuroendocrine markers, and most of them were positive for myoepithelial markers and/or HMWK. A combination of the above immunohistochemical markers seems useful to evaluate intraductal proliferative lesions and to predict their prognosis. In particular, intraductal proliferative lesions with solid components exhibiting positivity for neuroendocrine markers should be followed up carefully to monitor breast cancer risk or recurrence.es
dc.formatapplication/pdfes
dc.format.extent8es
dc.identifier.issn0213-3911
dc.identifier.urihttp://hdl.handle.net/10201/46922
dc.languageenges
dc.publisherMurcia: F. Hernándezes
dc.relation.ispartofHistology and histopathology, Vol. 26, nº 1 (2011)es
dc.rightsinfo:eu-repo/semantics/openAccesses
dc.subjectImmunohistochemistryes
dc.subjectPrognosises
dc.subject.other616 - Patología. Medicina clínica. Oncologíaes
dc.titleA useful immunohistochemical approach to evaluate intraductal proliferative lesions of the breast and to predict their prognosises
dc.typeinfo:eu-repo/semantics/articlees
dspace.entity.typePublicationes
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Histology and histopathology Vol.26, nº1 (2011)