Publication: A useful immunohistochemical approach
to evaluate intraductal proliferative lesions
of the breast and to predict their prognosis
Authors
Omi, Yoko ; Yamamoto, Tomoko ; Okamoto, Takahiro ; Obara, Takao ; Kobayashi, Makio
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Publisher
Murcia: F. Hernández
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Description
Abstract
An examination was performed on 16
intraductal proliferative breast lesions diagnosed as
intraductal papillomas (IP) or usual ductal hyperplasia
(UDH), which were followed up for more than 3 years.
An immunohistochemical marker panel combining
myoepithelial markers, high-molecular-weight keratin
(HMWK) and neuroendocrine markers was used. Two of
11 IP cases were re-evaluated as atypical ductal
hyperplasia (ADH) and ductal carcinoma in situ (DCIS).
These cases developed breast cancer after the first
operation. One IP case showed repeated recurrences.
None of the other IP and UDH cases had breast cancer
or recurrence. The ADH, DCIS and the recurrent IP
showing a solid growth lacked myoepithelia, but the
recurrent IP expressed HMWK, immunohistochemically.
Interestingly, these three lesions were weakly positive
for neuroendocrine markers. All other IPs and UDHs,
including lesions having solid components, were
negative for neuroendocrine markers, and most of them
were positive for myoepithelial markers and/or HMWK.
A combination of the above immunohistochemical
markers seems useful to evaluate intraductal
proliferative lesions and to predict their prognosis. In
particular, intraductal proliferative lesions with solid
components exhibiting positivity for neuroendocrine
markers should be followed up carefully to monitor
breast cancer risk or recurrence.
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