Publication: Extracellular vesicles derived from mesenchymal stem cells: A platform that can be engineered
Authors
Qin, Bo ; Zhang, Qi ; Chen, Dan ; Yu, Hai-yang ; Luo, Ai-xiang ; Suo, Liang-peng ; Cai, Yan ; Cai, De-yang ; Luo, Jia ; Huang, Ju-fang ; Xiong, Kun
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Publisher
Universidad de Murcia, Departamento de Biologia Celular e Histiologia
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DOI
https://doi.org/10.14670/HH-18-297
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info:eu-repo/semantics/article
Description
Abstract
y. Mesenchymal stem cells play an important
role in tissue damage and repair. This role is mainly due
to a paracrine mechanism, and extracellular vesicles
(EVs) are an important part of the paracrine function.
EVs play a vital role in many aspects of cell
homeostasis, physiology, and pathology, and EVs can be
used as clinical biomarkers, vaccines, or drug delivery
vehicles. A large number of studies have shown that EVs
derived from mesenchymal stem cells (MSC-EVs) play
an important role in the treatment of various diseases.
However, the problems of low production, low retention
rate, and poor targeting of MSC-EVs are obstacles to
current clinical applications. The engineering
transformation of MSC-EVs can make up for those
shortcomings, thereby improving treatment efficiency.
This review summarizes the latest research progress of
MSC-EV direct and indirect engineering transformation
from the aspects of improving MSC-EV retention rate,
yield, targeting, and MSC-EV visualization research, and
proposes some feasible MSC-EV engineering methods
of transformation.
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Citation
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