Publication: Apoptotic cell death in canine hair follicle
Authors
Pascucci, L. ; Pedini, V. ; Parillo, F. ; Gargiulo, A.M.
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Publisher
Murcia : F. Hernández
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DOI
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info:eu-repo/semantics/article
Description
Abstract
Apoptotic cell death is an essential
homeostatic mechanism involved in the control of
cellular turnover in a variety of adult tissues.
Cytoplasmic and nuclear condensation
morphologically define this process whose biochemical
hallmark is extensive DNA fragmentation into discrete
oligonucleosomic units.
Hair follicle growth and regression has been shown
to be correlated with apoptosis in humans, mice, rats and
guinea pigs.
The present study was carried out to evaluate its
implication in canine hair biology in order to define the
spatio-temporal relationship between apoptosis and the
hair cycle in dogs.
As assessed by terminal deoxy-nucleotidyl
transferase-mediated d-UTP nick-end-labelling
(TUNEL) and by basic histological and ultrastructural
assays, apoptotic cells appeared both in the growing and
in the regressing follicle epithelium showing the well
characterized morphological features described in the
previous relevant literature.
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