Publication: Apoptosis in gallbladder carcinomas and dysplasias, its relation to the expression of caspases 3,6 and 8 and apoptosis regulating proteins bcl-2, mcl-l and bax
Loading...
Date
2000
Authors
Turunen, N. ; Paakko, P. ; Solni, Y.
item.page.secondaryauthor
item.page.director
Publisher
Murcia : F. Hernández
publication.page.editor
publication.page.department
DOI
item.page.type
info:eu-repo/semantics/article
Description
Abstract
In this study we investigated apoptosis and
the expression of caspases 3, 6 and 8 and bcl-2, mcl-l
and bax in 39 gallbladder carcinomas and 7 epithelia1
dysplasias. The average apoptotic index was
0.68+0.91%. The extent of apoptosis was higher in grade
11-111 than grade I tumours or epithelial dysplasias
(p=0.003). Also, tumours invading beyond serosa or into
other organs (T3-T4) had a higher apoptotic index than
other tumours (p=0.05). Caspase 3 expression was found
in 37 (95%) and caspase 6 and 8 expression each in 30
(77%) carcinomas. Their expression associated with
each other and tended to increase along with the
progression of the lesions. Bcl-2 expression was found
in only 4 (10%) tumours. In contrast, mcl-l positivity
was found in 34 (87%) and bax positivity in all cases.
The results show that apoptosis is increased along with
progression of the neoplastic lesion of the gallbladder
epithelium. Caspases 3,6 and 8 are strongly expressed in
gallbladder carcinomas suggesting that they contribute to
the increased apoptosis observed in them. Of the bcl-2
family proteins, bcl-2 was expressed infrequently
suggesting that it does not play any significant role in
apoptosis inhibition in gallbladder tumours.
publication.page.subject
Citation
item.page.embargo
Ir a Estadísticas
Sin licencia Creative Commons.