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The emerging role of exosomes in survivin secretion

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dc.contributor.authorKhan, Salma
dc.contributor.authorFerguson Bennit, Heather
dc.contributor.authorWall, Nathan R.
dc.date.accessioned2020-01-29T15:09:24Z
dc.date.available2020-01-29T15:09:24Z
dc.date.issued2015
dc.description.abstractThe tumor microenvironment plays an integral part in the biology of cancer, participating in tumor initiation, progression, and response to therapy. Factors released by tumor cells themselves contribute in creating an environment mostly favorable but sometimes detrimental to the tumor. Survivin, one of the key members of the inhibitor of apoptosis (IAP) family of proteins, has been shown in the cytoplasm, mitochondria, nucleus, and most recently in the extracellular space, transported via small membrane bound vesicles called exosomes. Exosomes are secreted from hematopoietic, non-hematopoietic, tumor, and nontumor cells, shuttling essential molecules such as proteins, RNAs, and microRNAs, all believed to be important for cell-cell and cell-extracellular communication. In this review, we discuss exosomal Survivin and its role in modifying the tumor microenvironment.es
dc.formatapplication/pdfes
dc.format.extent8es
dc.identifier.doihttps://doi.org/10.14670/HH-30.43
dc.identifier.eisbnHistology and Histopathology, Vol. 30, n.º 1 (2015)es
dc.identifier.issn1699-5848
dc.identifier.issn0213-3911
dc.identifier.urihttp://hdl.handle.net/10201/86201
dc.languageenges
dc.publisherF. Hernández y Juan F. Madrid. Universidad de Murcia: Departamento de Biología Celular e Histologíaes
dc.rightsinfo:eu-repo/semantics/openAccesses
dc.rightsAttribution-NonCommercial-NoDerivatives 4.0 International*
dc.rights.urihttp://creativecommons.org/licenses/by-nc-nd/4.0/*
dc.subjectSurvivines
dc.subjectTumor microenvironmentes
dc.subjectExosomeses
dc.subject.otherCDU::5 - Ciencias puras y naturales::57 - Biología::576 - Biología celular y subcelular. Citologíaes
dc.titleThe emerging role of exosomes in survivin secretiones
dc.typeinfo:eu-repo/semantics/articlees
dspace.entity.typePublicationes
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Histology and histopathology Vol.30, nº1 (2015)