Publication: The emerging role of exosomes in survivin secretion
Authors
Khan, Salma ; Ferguson Bennit, Heather ; Wall, Nathan R.
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Publisher
F. Hernández y Juan F. Madrid. Universidad de Murcia: Departamento de Biología Celular e Histología
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DOI
https://doi.org/10.14670/HH-30.43
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info:eu-repo/semantics/article
Description
Abstract
The tumor microenvironment plays an
integral part in the biology of cancer, participating in
tumor initiation, progression, and response to therapy.
Factors released by tumor cells themselves contribute in
creating an environment mostly favorable but sometimes
detrimental to the tumor. Survivin, one of the key
members of the inhibitor of apoptosis (IAP) family of
proteins, has been shown in the cytoplasm,
mitochondria, nucleus, and most recently in the
extracellular space, transported via small membrane
bound vesicles called exosomes. Exosomes are secreted
from hematopoietic, non-hematopoietic, tumor, and nontumor cells, shuttling essential molecules such as
proteins, RNAs, and microRNAs, all believed to be
important for cell-cell and cell-extracellular
communication. In this review, we discuss exosomal
Survivin and its role in modifying the tumor
microenvironment.
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Citation
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