Publication: CD9 expression in vascular aging and atherosclerosis
Authors
Kim, Jae-Ryong ; Cho, Joon Hyuk
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Publisher
Universidad de Murcia, Departamento de Biologia Celular e Histiologia
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DOI
https://doi.org/10.14670/HH-18-268
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info:eu-repo/semantics/article
Description
Abstract
CD9 is a transmembrane glycoprotein
belonging to the tetraspanin family. CD9 expression has
been reported to be associated with cellular signaling,
cell adhesion, cell migration, and tumor related
processes. The aim of this study was to examine the
immunohistochemical expression of CD9 in vascular
senescence and atherosclerosis. One hundred and twenty
samples of normal young arteries (obtained from
individuals aged 0-60 years), 40 samples of normal old
arteries (obtained from individuals aged 61-80 years),
and 67 samples of atherosclerotic arteries were obtained
from surgically resected specimens. Tissue microarray
blocks were prepared for immunohistochemical staining.
Immunohistochemical staining detected CD9 expression
in 10.8% (13 of 120 samples) of normal young arteries
and 30.0% (12 of 40 samples) of normal old arteries.
CD9 expression was absent or mildly present in the
smooth muscle cells and endothelial cells of normal
arteries. Normal old arteries showed significantly higher
expression of CD9 than normal young arteries (P<0.01).
Atherosclerotic arteries showed moderate or strong CD9
expression (65 of 67 samples, 97.0%), which was
observed in the smooth muscle cells, endothelial cells,
macrophages, and atheromatous plaques. CD9 was
significantly expressed in the atherosclerotic arteries
compared to normal young and old arteries (P<0.01).
The results suggest that CD9 expression may play an
important role in the vascular senescence and
pathogenesis of atherosclerosis.
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