Browsing by Subject "Artery"

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    CD9 expression in vascular aging and atherosclerosis
    (Universidad de Murcia, Departamento de Biologia Celular e Histiologia, 2020) Kim, Jae-Ryong; Cho, Joon Hyuk
    CD9 is a transmembrane glycoprotein belonging to the tetraspanin family. CD9 expression has been reported to be associated with cellular signaling, cell adhesion, cell migration, and tumor related processes. The aim of this study was to examine the immunohistochemical expression of CD9 in vascular senescence and atherosclerosis. One hundred and twenty samples of normal young arteries (obtained from individuals aged 0-60 years), 40 samples of normal old arteries (obtained from individuals aged 61-80 years), and 67 samples of atherosclerotic arteries were obtained from surgically resected specimens. Tissue microarray blocks were prepared for immunohistochemical staining. Immunohistochemical staining detected CD9 expression in 10.8% (13 of 120 samples) of normal young arteries and 30.0% (12 of 40 samples) of normal old arteries. CD9 expression was absent or mildly present in the smooth muscle cells and endothelial cells of normal arteries. Normal old arteries showed significantly higher expression of CD9 than normal young arteries (P<0.01). Atherosclerotic arteries showed moderate or strong CD9 expression (65 of 67 samples, 97.0%), which was observed in the smooth muscle cells, endothelial cells, macrophages, and atheromatous plaques. CD9 was significantly expressed in the atherosclerotic arteries compared to normal young and old arteries (P<0.01). The results suggest that CD9 expression may play an important role in the vascular senescence and pathogenesis of atherosclerosis.
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    Distribution and microstructure of intrarenal arteries in Bactrian camels (Camelus bactrianus)
    (Universidad de Murcia, Departamento de Biologia Celular e Histiologia, 2020) Li, Hui; Cui, Yan; Wang, Yali; Qiu, Haiyu; Afedo, Seth Yaw; Huang, Yufeng; Bai, Xuefeng
    Studies and reports focusing on the Bactrian camels’ kidney structure from an anatomical perspective are scanty, therefore, this work aims to systemically investigate the anatomical structure of the kidney and examine the distribution and microstructure of intrarenal arteries. Ten pairs of healthy adult kidneys from male and female Bactrian camels were used in the study. The kidney of Bactrian camel appeared like a broad bean with a smooth surface. Using artery casting, we observed that the renal artery divided into dorsal and ventral branches; the dorsal branch continuously divided into a shorter anterior branch and a longer posterior branch, while the ventral branch directly divided into interlobar arteries. The number of interlobar arteries in the left and right kidneys were slightly different, 14 to 16 in left while 16 in the right kidney. No anastomosis was found between the dorsal and ventral branches or their sub- branches. To further study the microscopic structure, microanatomy and scanning microscope were used. Surprisingly, we observed two other ways afferent arteriole arose apart from the interlobular artery. They were the arcuate artery and conjoint afferent arteriole. Two afferent arterioles supplied one glomerulus and occasionally the absence of glomerulus was also observed, where the arteriole kept extending, and no typical glomerulus formed. Since branching of arteries and urologic function of kidneys are physiologically integrated, these features of Bactrian camel may help to further investigate their adaptations to desert climate.