Publication: Biotechnological approach to increase oxyresveratrol production in mulberry in vitro plants under elicitation
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Date
2023-01-25
Authors
Sabater Jara, Ana Belén ; Almagro, Lorena ; Nicolás Sánchez, Isabel ; Pedreño, María Angeles
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Publisher
MDPI
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DOI
https://doi.org/10.3390/ plants12030546
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info:eu-repo/semantics/article
Description
© 2023 by the authors. This manuscript version is made available under the CC-BY 4.0 license http://creativecommons.org/licenses/by/4.0/
This document is the Published Manuscript version of a Published Work that appeared in final form in Plants. To access the final edited and published work see https://doi.org/10.3390/plants12030546
Abstract
Morus alba L. is used for a range of therapeutic purposes in Asian traditional medicine,
and its extracts are reported to be effective against lipidemia, diabetes, and obesity, as well as being hepatoprotective and tyrosinase-inhibitory. They are also included in cosmetic products as
anti-aging and skin-whitening agents. Stilbenes, the major bioactive compounds found in M. alba,
have received renewed attention recently because of their putative activity against COVID-19. In
this study M. alba plants were established in vitro, and the effect of elicitation on plant growth and
stilbene accumulation, specifically oxyresveratrol and trans-resveratrol, was investigated. Different
concentrations of the elicitors including methyl jasmonate and cyclodextrins were applied, and
stilbene levels were determined in leaves, roots, and the culture medium. Elicitation of the M. alba
plants with 5 mM cyclodextrins, alone or in combination with 10 µM methyl jasmonate, significantly
increased the total phenolic content in the culture medium and leaves after 7 days of treatment. The
higher total phenolic content in the roots of control plants and those treated only with methyl jasmonate indicated that cyclodextrins promoted metabolite release to the culture medium. Notably, the
cyclodextrin-treated plants with the highest levels of oxy- and trans-resveratrol also had the highest
total phenolic content and antioxidant capacity. These results indicate that elicited M. alba in vitro
plants constitute a promising alternative source of bioactive stilbenes to supply pharmaceutical and
cosmeceutical industries.
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Citation
Plants, 2023, Vol. 12(3) : 546
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Este ítem está sujeto a una licencia Creative Commons. CC BY 4.0