Publication: The protective effects of a prostaglandin without antisecretory properties aginst ethanol-induced injury in the rat stomach, a histologic study
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Date
1987
Authors
Schmidt, Carmen L. ; Henagan, Julia M. ; Mitchell, Philip A. ; Smith, Gregory S. ; Miller, Thomas A.
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Publisher
Murcia : F. Hernández
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DOI
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info:eu-repo/semantics/article
Description
Abstract
This study examined the effect of 2-acetyl-2-
decarboxy-15(S)-15 methyl PGF,, (PGF,,) on ethanol
(EtOH) induced injury in the rat stomach to determine if a
PG analogue devoid of antisecretory properties could confer
full or partial gastric mucosal protection. Rats were orally
administered saline or PGF,, in a dose of 0.5 or 5.0 mg1Kg.
Thirty minutes later animals received varying concentrations
(i.e. 25%, 50%, and 100%) of EtOH orally. Five minutes
following EtOH exposure, they were killed and samples
taken from identical regions of the glandular mucosa for
microscopic evaluation. All concentrations of EtOH tested
damaged the gastric epithelium. The injury induced by 25%
EtOH was almost exclusively confined to the surface
epithelium and was not altered by either dose of PGF,,,
pretreatment. In contrast, both 50% and 1(10% EtOH
elicited comparable damage to the gastric mucosa involving
both the deep and superficial mucosa of virtually the entire
epithelium. The deep injury induced by these two EtOH
concentrations was prevented by both the low and high dose
of PGF,,. Of particular importance the 5.0 mg dose of PGF,
provided complete protection (i.e. both superficial and deep)
to as much as 50% of the mucosa exposed to 50% or 100%
ethanol. These findings indicate that PGF?, possesses
~~cytoprotectivep*r operties involving both the superficial
and deep epithelium that are dose related.
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