Publication: Chitosan-Alginate Blended Nanoparticles as Carriers for the Transmucosal Delivery of Macromolecules
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Date
2009-06-22
Authors
Goycoolea Valencia, Francisco Martín ; Giovanna Lollo ; Carmen Remuñán-López ; Fabiana Quaglia ; María J. Alonso
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Facultades de la UMU::Facultad de Biología
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Publisher
American Chemical Society
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DOI
https://doi.org/10.1021/bm9001377
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info:eu-repo/semantics/article
Description
Abstract
Nanoparticles intended for use in the transmucosal delivery of macromolecules were prepared by the ionic gelation of chitosan (CS) hydrochloride with pentasodium tripolyphosphate (TPP) and concomitant complexation with sodium alginate (ALG). The incorporation of a small proportion of ALG of increasing molecular weight (Mw; from 4 to 74 kDa) into the nanoparticles led to a monotonic increase in colloidal size from ∼260 to ∼525 nm. This increase in size was regarded as a consequence of the formation of radually more expanded structures. Insulin, taken as a model peptide, was associated to CS-TPP-ALG nanoparticles with efficiencies in the range of ∼41 to ∼52%, irrespective of the Mw of the ALG incorporated in the formulation. These CS-TPP-ALG nanoparticles exhibited a capacity to enhance the systemic absorption of insulin after nasal administration to conscious rabbits. Interestingly, it was observed that the duration of the hypoglycaemic response was affected by the ALG’s Mw. Briefly, this work describes a new nanoparticulate composition of potential value for increasing nasal insulin absorption.
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Citation
Goycoolea F.M., Lollo G., Remuñán-López C., Quaglia F., *Alonso M.J. (2009). Chitosan–alginate blended nanoparticles as carriers for transmucosal delivery of macromolecules. Biomacromolecules, 10, 1736-1743.
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