Publication: Ground-glass hepatocytes. ligth and electron microscopy. Characterization of the different types
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Date
1990
Authors
Jaime Vázquez, J.
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Publisher
Murcia : F. Hernández
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DOI
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info:eu-repo/semantics/article
Description
Abstract
Morphological observations of paraffinembedded
histological sections stained with H&E led to
the discovery of some cytoplasmic changes which occur
in different conditions, although they look alike under
the light microscope. These hepatocytic changes
consisted basically of homogeneous areas which are
weakly eosinophilic in H & E-stained sections. They are
frequently referred to as «inclusion» bodies, even when
they are not true inclusions. The hepatocytic changes
obsewed in HBsAg carriers, in chronic alcoholic
patients treated with cyanamide to discourage them from
drinking alcohol, in Lafora's disease, and in glycogenosis
type IV, look very similar in paraffin sections stained
with H&E. Nevertheless, they can be differentiated
using ancillary techniques. On electron microscopy they
do not look alike. Of particular interest are the
«inclusion» bodies induced by cyanamide, a predictable
and reproductible lesion, which in man eventually leads
to cirrhosis.
Other types of hepatocytic changes also giving a
rather vague eground-glass» appearance to the
cytoplasm are those resulting from intracytoplasmic
accumulation of proteins, particularly fibrinogen, and
those observed in patients treated with different drugs.
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