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Dynamic patterns of colocalization of calbindin, parvalbumin and GABA in subpopulations of mouse basolateral amygdalar cells during development

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dc.contributor.authorDávila, José Carlos
dc.contributor.authorOlmos, Luis
dc.contributor.authorLegaz Pérez, Isabel
dc.contributor.authorMedina, Loreta
dc.contributor.authorGuirado, Salvador
dc.contributor.authorReal, Mª Angeles
dc.contributor.departmentCiencias Sociosanitarias
dc.date.accessioned2024-07-12T08:23:17Z
dc.date.available2024-07-12T08:23:17Z
dc.date.issued2008-01
dc.description© 2007 Elsevier B.V. This document is the Published version of a Published Work that appeared in final form in Journal of Chemical Neuroanatomy. To access the final edited and published work see https://doi.org/10.1016/j.jchemneu.2007.06.003
dc.description.abstractCalbindin cells represent a major interneuron subtype of the cortical/pallial regions, such as the basolateral amygdala, which are often analyzed in studies of tangential migration of interneurons from the subpallial ganglionic eminences to the pallium/cortex. However, previous evidence suggests that during development the calbindin cells may include more than one of the interneuron subtypes found in the adult pallium/cortex. Furthermore, in the adult basolateral amygdala, calbindin cells include a subpopulation of non-GABAergic (non-interneuron) cells. To better characterize these cells throughout development, in the present study we investigated the colocalization of calbindin, parvalbumin and GABA in cells of the mouse basolateral amygdala during late embryonic (E16.5) and several postnatal ages from birth until 4 weeks after birth (P0, P10 and P28). Our results indicate that CB, PV and GABA show a dynamic pattern of colocalization in cells of the mouse basolateral amygdalar nucleus throughout development. From E16.5 through P28, the majority of CB+ neurons and virtually all PV+ neurons are GABAergic. However, after P10, the percentage of GABAergic CB+ cells decline from 96% to 70%. Furthermore, while only 9% of CB+ neurons are PV+ at P10, this percentage raises to 42% at P28. At all postnatal ages studied, the majority of the PV+ cells are CB+, suggesting that PV+ interneurons develop postnatally mainly as a subpopulation within the CB+ cells of the basolateral amygdalar nucleus. These results are important for interpreting data from interneuron migration.es
dc.embargo.termsSI
dc.formatapplication/pdfes
dc.format.extent10es
dc.identifier.citationJournal of Chemical Neuroanatomy, 2008, Vol. 35, Issue 1, pp. 67-76
dc.identifier.doihttps://doi.org/10.1016/j.jchemneu.2007.06.003
dc.identifier.issnPrint: 0891-0618
dc.identifier.issnElectronic: 1873-6300
dc.identifier.urihttp://hdl.handle.net/10201/143051
dc.languageenges
dc.publisherElsevier
dc.relationThis work was supported by Spanish BFU2006-14804-C02-01/BFI and BFU2006-14804-C02-02/BFI.es
dc.relation.publisherversionhttps://www.sciencedirect.com/science/article/pii/S0891061807001202?via%3Dihub#aep-acknowledgment-id27
dc.rightsinfo:eu-repo/semantics/embargoedAccesses
dc.subjectInterneuronses
dc.subjectCalcium binding proteinses
dc.subjectPallial amygdalaes
dc.subjectNeuroanatomyes
dc.subjectImmunohistochemistryes
dc.titleDynamic patterns of colocalization of calbindin, parvalbumin and GABA in subpopulations of mouse basolateral amygdalar cells during developmentes
dc.typeinfo:eu-repo/semantics/articlees
dspace.entity.typePublicationes
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