Publication: Carbohydrate cytochemistry of bonnet monkey (Macaca radiaca) nasal epithelium. Response to ambient levels of ozone
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Date
1992
Authors
Dimitriadis, V.K.
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Publisher
Murcia : F. Hernández
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DOI
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info:eu-repo/semantics/article
Description
Abstract
The main purpose of this study was to
determine whether exposures to ambient levels of ozone
induced changes in the carbohydrate content in the
anterior nasal cavity of bonnet monkey. Monkeys were
exposed to 0.00. 0.15, or 0.30 ppm of ozone for 6 or 90
days, 8 hours / day. Monkeys treated for 90 days to 0.15
or 0.30 ppm of ozone displayed damaged ciliated cells
and a new cell type in their respiratory nasal epithelium,
the «intermediate» cells possessing morphological
characteristics of both ciliated and secretory cells.
Characterization of the secretory cell carbohydrates with
the PA-TCH-SP, HID-TCH-SP and LID-TCH-SP
techniques indicated the existence of periodate-reactive
sulfated and carboxylated polysaccharides in both treated
and control monkeys. Ozone-inhalation, however,
induced the appearance of a large number of mucous cells
with dilated cisternae of rough endoplasmic reticulum
compared to controls, which reacted negatively for sugar
presence. In addition, in the respiratory epithelium ozone
induced the increase of cells with intracytoplasmic
lumina containing material reacted positively for sulfated
and carboxylated polysaccharides.
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