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Are there differences in basal thrombophilias and C-reactive protein between women with or without PCOS?

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dc.contributor.authorSánchez-Ferrer, María L.
dc.contributor.authorPrieto-Sánchez, María T.
dc.contributor.authorCorbalán-Biyang, , Shiana
dc.contributor.authorMendiola, Jaime
dc.contributor.authorAdoamnei, Evdochia
dc.contributor.authorHernández-Peñalver, Ana L.
dc.contributor.authorCarmona-Barnosi, Ana
dc.contributor.authorSalido-Fiérrez, Eduardo J.
dc.contributor.authorTorres-Cantero, Alberto M.
dc.contributor.departmentCirugía, Pediatría y Obstetricia y Ginecología
dc.date.accessioned2024-02-11T12:59:44Z
dc.date.available2024-02-11T12:59:44Z
dc.date.issued2009-02
dc.description.abstractPolycystic ovary syndrome (PCOS) women have increased cardiovascular risks, although it is unclear whether the haemostatic system and coagulation contribute to that increased risk. Women attending the Gynecology Unit of the 'Virgen de la Arrixaca' University Hospital (Murcia, Spain) for routine gynaecological examinations between September 2014 and May 2016 were assessed for PCOS using the Rotterdam criteria (hyperandrogenism [H], oligo/amenorrhoea [O] and polycystic ovarian morphology [POM]) and were classified into four phenotypic. In total, 126 cases were identified and 159 control women were selected. All women underwent physical and gynaecological examinations, and blood tests between the second and fifth day of the menstrual cycle. Differences in hormonal, basal thrombophilia and metabolic parameters, and C-reactive protein (CRP) between PCOS and controls were analysed. After adjusting by BMI and age, PCOS women had higher LH (P < 0.001), testosterone (P < 0.001), free testosterone (P = 0.01) and anti-Müllerian hormone (P < 0.001) and lower FSH (P = 0.03) compared with controls, whereas sex hormone-binding globulin was no different. Cases showed significantly higher protein S, glucose, insulin and insulin resistance (HOMA-IR) compared with controls (P < 0.05). There were no differences in protein C levels, antithrombin III, prothrombin time, homocysteine, D-dimer, factor V Leyden, prothrombin G20210A polymorphism or CRP. The H+O phenotype showed the poorest results for insulin and HOMA-IR (P = 0.04 and 0.05). The results suggest that there are no differences in the basal thrombophilias between women with and without PCOS. However, PCOS with H+O shows the poorest metabolic profile.es
dc.embargo.termsSi
dc.formatapplication/pdfes
dc.format.extent9es
dc.identifier.doihttps://doi.org/10.1016/j.rbmo.2019.01.013
dc.identifier.eisbnReproductive Biomedicine Online. 2019 Jun;38(6):1018-1026es
dc.identifier.issn1472-6483
dc.identifier.urihttp://hdl.handle.net/10201/139241
dc.languageenges
dc.relationThis work was supported by the Ministry of Economy and Competitiveness, ISCIII (AES), grant no. PI13/01237; and The Seneca Foundation, Murcia Regional Agency of Science and Technology, grant no. 19443/PI/14.es
dc.rightsinfo:eu-repo/semantics/embargoedAccesses
dc.subject.otherCDU::6 - Ciencias aplicadas::61 - Medicina::618 - Ginecología. Obstetriciaes
dc.titleAre there differences in basal thrombophilias and C-reactive protein between women with or without PCOS?es
dc.typeinfo:eu-repo/semantics/articlees
dspace.entity.typePublicationes
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