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Study of oxyresveratrol complexes with insoluble cyclodextrin based nanosponges: Developing a novel way to obtain their complexation constants and application in an anticancer study

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dc.archivorevisadoOxyresveratrol
dc.contributor.authorMatencio, Adrián
dc.contributor.authorKumar Dhakarb, Nilesh
dc.contributor.authorBessonec, Federica
dc.contributor.authorMusso, Giorgia
dc.contributor.authorCavallic, Roberta
dc.contributor.authorDianzanic, Chiara
dc.contributor.authorGarcía Carmona, Francisco
dc.contributor.authorLópez Nicolás, José Manuel
dc.contributor.departmentBioquímica y Biología Molecular Aes
dc.date.accessioned2024-02-10T17:50:23Z
dc.date.available2024-02-10T17:50:23Z
dc.date.issued2019-12-17
dc.description©2019. This manuscript version is made available under the CC-BY-NC-ND 4.0 license http://creativecommons.org/licenses/by-nc-nd/4.0/ This document is the Accepted, version of a Published Work that appeared in final form in Carbohydrate Polymers. To access the final edited and published work see https://doi.org/10.1016/j.carbpol.2019.115763
dc.description.abstractThe complexation of the bioactive compound oxyresveratrol (OXY) with a polymer called cyclodextrin-based nanosponge (CD-NS) and its application was studied.A new methodology is used to calculate, an apparent inclusion complex constant (KFapp) between a ligand and CD-NSs. Moreover, the KFapp of resveratrol was also evaluated and compared. The complex of OXY with the nanosponge β-CDI 1:4, was studied in vitro using DSC, TGA and FTIR techniques and its drug loading and release behavior were studied. An in vitro digestion showed higher protection of OXY complexed than free OXY. The bioactivity enhancing capacity of OXY was also studied against prostate (PC-3) and colon (HT-29 and HCT-116) cancer cell lines, where it showed stronger cell viability inhibition than the free drug. The findings as a whole represent a new opportunity for studying the complexation of drugs in CD-NSs and the use of oxyresveratrol as an ingredient in nutraceutical products.es
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dc.format.extent7
dc.identifier.doihttps://doi.org/10.1016/j.carbpol.2019.115763
dc.identifier.eisbnCarbohydrate Polymers 231 (2020) 115763es
dc.identifier.issnPrint: 0144-8617
dc.identifier.issnElectronic: 1879-1344
dc.identifier.urihttp://hdl.handle.net/10201/139200
dc.languageenges
dc.publisherElsevier
dc.relationThis work was supported by the Spanish Ministry of Economy and Competitiveness (MEC-FEDER, Spain) (Project AGL2017-86526) and by the “Programa de Ayudas a Grupos de Excelencia de la Región de Murcia, FundaciónSéneca, Agencia de Ciencia y Tecnología de la Región de Murcia” (Project 19893/GERM/15). AdriánMatencio holds a “FPU UM” contract from the University of Murcia (R-1042/2015), and held an Erasmus+traineeship and an “Ayudapara estancias Breves” from the University of Murcia (R-403/2018) to carry out this collaboration.es
dc.rightsinfo:eu-repo/semantics/embargoedAccesses
dc.rightsAttribution-NonCommercial-NoDerivatives 4.0 Internacional
dc.subjectStilbene
dc.subjectCyclodextrins
dc.subjectAnticancer
dc.subjectNanosponges
dc.subjectMethodology
dc.titleStudy of oxyresveratrol complexes with insoluble cyclodextrin based nanosponges: Developing a novel way to obtain their complexation constants and application in an anticancer studyes
dc.typeinfo:eu-repo/semantics/articlees
dspace.entity.typePublicationes
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