Publication: Pathological change of articular cartilage in the mandibular
head treated with immunosuppressant FK 506
Authors
Ueno, T. ; Kagawa, T. ; Kanou, M. ; Fujii, T. ; Fukunaga, J. ; Mizukawa, N. ; Sugahara, T. ; Yamamoto, T.
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Publisher
Murcia : F. Hernández
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DOI
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info:eu-repo/semantics/article
Description
Abstract
While several reports have documented
immunosuppressant-induced osteoporosis, the exact
mechanism of the pathological change of the joint
remains to be clarified. In the present study, we have
demonstrated the pathological change of the articular
cartilage in the mandibular head of five Sprague-Dawley
rats administered with the immunosuppressant FK 506
for 28 days. Three-dimensional micro-computed
tomography of the mandibular heads in treated rats
showed a significant decrease in trabecular bone volume
compared to control rats. Histological observation
revealed atrophic change of the articular cartilage.
Immunohistological observation using anti-proliferative
cell nuclear antibody (PCNA), type I, II, and type X
collagen antibodies showed significantly decreased
proliferation and differentiation of chondrocytes in the
articular cartilage compared with the control group
(p<0.05). Tartrate-resistant acid phosphatase (TRAP)
staining revealed no significant difference in the
numbers of osteoclasts at the chondro-osseous junction.
Thus, FK 506 administration inhibited chondrogenic cell
proliferation and differentiation and might cause
osteoporotic change of subcartilage trabecular bone that
subsequently forms in the mandibular head
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