Publication:
CDK9: a key player in cancer and other diseases

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CDK9 JCB new format_50refs.pdf(287.7 KB)
Date
2017-07-19
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Authors
Franco, Lia Carolina ; Morales, Fátima ; Boffo, Silvia ; Giordano, Antonio
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Publisher
Wiley
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Química Orgánica
Description
© 2017 Wiley Periodicals, Inc. This document is the Submitted version of a Published Work that appeared in final form in Journal of Cellular Biochemistry. To access the final edited and published work see https://doi.org/10.1002/jcb.26293
Abstract
Cyclin-Dependent Kinase 9 (CDK9) is part of a functional diverse group of enzymes responsible for cell cycle control and progression. It associates mainly with Cyclin T1 and forms the Positive Transcription Elongation Factor b (p-TEFb) complex responsible for regulation of transcription elongation and mRNA maturation. Recent studies have highlighted the importance of CDK9 in many relevant pathologic processes, like cancer, cardiovascular diseases, and viral replication. Herein we provide an overview of the different pathways in which CDK9 is directly and indirectly involved.
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Cancer pathway , CDK9 , Cyclin , Drug targeting , Kinase , Transcription regulation , Viral replication
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http://hdl.handle.net/10201/144343
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