Publication:
Observations on cell kinetics and viability of a human melanoma cell line exposed to dicarboxylic acids in tissue culture

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Observations on cell kinetics and viability of a human melanoma cell line exposed to dicarboxylic acids in tissue culture.pdf(427.33 KB)
Date
1986
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Authors
Breathnach, A. S. ; Robins, E.J. ; Bhasin, Y. P. ; Ethridge, L. B. ; Nazzaro-Porro, M. ; Passi, S. ; Picardo, M.
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Publisher
Murcia : F. Hernández
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DOI
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info:eu-repo/semantics/article
Description
Abstract
Cultures of human nlelanonla cell line BOO08 \verc e-iposed to the disodium salts of arelaic acid (C,, 2Na), adipic acid (C,, 2Na) and dodecanediaic acid (C,, 2Na) at IO'M and 5 x 10-'M for 24 hrs. None of the diacid salts had a significant effect on growth rate or viability of the cells, at 10-'M for 24 hrs nor had C, 2Na any effect at 5 x 10'M. At 5 x 102M for 24 hrs, both C,, 2Na, and CIL2 Na had a significant effect in reducing both growth and viability. These effects were accompanied by morphological evidence of cell death, and swelling of mitochondria and accuni~~latioonf lipid droplets within cytoplasm of still biable cells.
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Melanoma , Dicarboxylic acids
Citation
URI
http://hdl.handle.net/10201/17825
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Histology and histopathology Vol. 1, nº 3 (1986)
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