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Expression of inwardly rectifying K+ channels in the carotid body of rat

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dc.contributor.authorYamamoto, Y.es
dc.contributor.authorIshikawa, R.es
dc.contributor.authorOmoe, K.
dc.contributor.authorTaniguchi, K.
dc.date.accessioned2013-01-18T13:35:16Z
dc.date.available2013-01-18T13:35:16Z
dc.date.issued2008
dc.description.abstractThe inwardly rectifying K+ channels, Kir1.1, Kir2.3, Kir4.1-Kir5.1, and Kir4.2-Kir5.1, are candidate chemosensory molecules for CO2/H+. Here, we determined the mRNA expression and immunohistochemical localization of these channels in the carotid body (CB) and petrosal ganglion (PG) of the rat. RT-PCR analysis revealed mRNA expression of Kir4.1 and Kir5.1 in CB, and Kir1.1, Kir4.1, and Kir5.1 in PG. Immunohistochemistry identified the glomus cells in CB to express both Kir4.1 and Kir5.1 protein, while the nerve fibers in CB were immunoreactive for Kir1.1, Kir4.1, and Kir5.1. In the PG, immunoreactivity for Kir1.1, Kir4.1, and Kir5.1 was observed in some ganglion cells. Our findings suggest that Kir channels in the peripheral chemoreceptors play a role in sensing hypercapnic acidosis and maintaining the resting membrane potentials.es
dc.formatapplication/pdfes
dc.format.extent8es
dc.identifier.issn0213-3911es
dc.identifier.urihttp://hdl.handle.net/10201/29698
dc.languageenges
dc.publisherMurcia : F. Hernándezes
dc.relation.ispartofHistology and histopathologyes
dc.rightsinfo:eu-repo/semantics/openAccesses
dc.subjectCarotid bodyes
dc.subjectPetrosal gangliones
dc.subject.other576 - Biología celular y subcelular. Citologíaes
dc.titleExpression of inwardly rectifying K+ channels in the carotid body of rates
dc.typeinfo:eu-repo/semantics/articlees
dspace.entity.typePublicationes
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Histology and histopathology Vol.23, nº7 (2008)