Publication: Physical frailty characteristics have a differential impact on symptoms as measured by the CAT score: an observational study
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Date
2018-07-16
Authors
Medina Mirapeix, Francesc ; Bernabeu Mora, Roberto ; Giménez Giménez, Luz María ; Escolar Reina, Pilar ; Gacto Sánchez, Mariano ; Oliveira-Sousa, Silvana Loana de
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Publisher
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DOI
10.1186/s12955-018-0969-9
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info:eu-repo/semantics/article
Description
©2018. This manuscript version is made available under the CC-BY 4.0 license http://creativecommons.org/licenses/by-nc-nd/4.0/
This document is the Published, version of a Published Work that appeared in final form in Health and Quality of Life Outcomes. To access the final edited and published work see https://doi.org/10.1186/s12955-018-0969-9
Abstract
BACKGROUND: The physical frailty status affects the health status of patients
with chronic obstructive pulmonary disease (COPD). The objective was to
determine if the individual physical frailty characteristics have a differential
impact on the CAT score.
METHODS: This observational study included 137 patients with stable COPD.
Physical frailty was measured with unintentional weight loss, low physical
activity, exhaustion, slow walking speed and low grip strength and health status
assessed with the COPD Assessment test (CAT). The following variables were
evaluated as potential determinants of CAT: sex, age, body mass index, smoking,
dyspnea, exacerbations, comorbidities, %FEV1, %FVC, anxiety and depression.
RESULTS: The prevalence of characteristics for individual frailty was as
follows: low grip strength, 60.6%; low physical activity, 27.0%; exhaustion,
19.7%; slow walking speed, 9.5%; and unintentional weight loss, 7.3%. A total of
17.5% of the patients were non-frail, 73.7% were pre-frail and only 8.7% were
frail. One of the five frailty characteristics, exhaustion (adjusted β
coefficient 5.12 [standard error = 1.27], p = 0.001) was an independent
determinant of CAT score in the final regression model which was adjusted by
other independent determinants of CAT (dyspnea, exacerbations and anxiety).
CONCLUSIONS: Due to the fact that exhaustion is a frequent and relevant
psychological symptom on CAT score of patients with COPD, interventions should
reduce that stress. Future research should explore how exhaustion persists or
remits over time.
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Citation
Health Qual Life Outcomes. 2018 Jul 16 16(1):140
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Este ítem está sujeto a una licencia Creative Commons. http://creativecommons.org/licenses/by-nc-nd/4.0/